Prenatal alcohol exposure and the neuroapoptosis with long-term effect in visual cortex of mice

被引：21

作者：

Jiang, Qiying ^{[1
]}

Hu, Yanqiu ^{[1
]}

Wu, Ping ^{[1
]}

Cheng, Xiangshu ^{[1
]}

Li, Mingshan ^{[1
]}

Yu, Dongming ^{[1
]}

Deng, Jinbo ^{[1
]}

机构：

[1] Henan Univ, Inst Neurobiol, Jinming Campus, Kaifeng 475004, Henan Province, Peoples R China

来源：

ALCOHOL AND ALCOHOLISM | 2007年 / 42卷 / 04期

关键词：

D O I：

10.1093/alcalc/agm032

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Aims: The prenatal ethanol exposure induced neuroapoptosis and neuron loss in visual cortex would be investigated in mice at PO, P7 and P14. Methods: Intubating pregnant mice ethanol daily began on E5 and continued through the pup's birth. The neuroapoptosis in visual cortex was visualized by the caspase 3 immunocytochemistry, and the neuron loss was observed with Nissl method as well. Results: With prenatal ethanol exposure, the dose-dependent neuroapoptosis and neuron loss in visual cortex could be found at PO and even at P7 and P14 as well. Conclusions: The prenatal ethanol exposure induced neuroapoptosis and neuron loss will persist into postnatal stage, and the long-term effect of neuroapoptosis might be one of the causes of postnatal neurobehavioural disturbances associated with fetal alcohol syndrome.

引用

页码：285 / 290

页数：6

共 39 条

[1]

ABEL EL, 1986, LANCET, V2, P1222

[2] Acute and chronic effects of alcohol on preattentive auditory processing as reflected by mismatch negativity [J].

Ahveninen, J ;

Escera, C ;

Polo, MD ;

Grau, C ;

Jääskeläinen, IP .

AUDIOLOGY AND NEURO-OTOLOGY, 2000, 5 (06) :303-311

[3] CELL-MIGRATION IN THE RAT EMBRYONIC NEOCORTEX [J].

BAYER, SA ;

ALTMAN, J ;

RUSSO, RJ ;

DAI, XF ;

SIMMONS, JA .

JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 307 (03) :499-516

[4] PLANAR DIFFERENCES IN NUCLEAR-AREA AND ORIENTATION IN THE SUBVENTRICULAR AND INTERMEDIATE ZONES OF THE RAT EMBRYONIC NEOCORTEX [J].

BAYER, SA ;

ALTMAN, J ;

DAI, XF ;

HUMPHREYS, L .

JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 307 (03) :487-498

[5]

Blaschke AJ, 1996, DEVELOPMENT, V122, P1165

[6] THIAMINE-DEPENDENT ENZYME CHANGES IN THE BRAINS OF ALCOHOLICS - RELATIONSHIP TO THE WERNICKE-KORSAKOFF-SYNDROME [J].

BUTTERWORTH, RF ;

KRIL, JJ ;

HARPER, CG .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1993, 17 (05) :1084-1088

[7] Rearranging views on neurogenesis: Neuronal death in the absence of DNA end-joining proteins [J].

Chun, J ;

Schatz, DG .

NEURON, 1999, 22 (01) :7-10

[8] Animal model systems for the study of alcohol teratology [J].

Cudd, TA .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2005, 230 (06) :389-393

[9] Corpus callosum and visual cortex of mice with deletion of the NMDA-NR1 receptor - II. Attenuation of prenatal alcohol exposure effects [J].

Deng, JB ;

Elberger, AJ .

DEVELOPMENTAL BRAIN RESEARCH, 2003, 144 (02) :135-150

[10] Ethanol-induced neuroapoptosis in the developing rodent cerebellum and related brain stem structures [J].

Dikranian, K ;

Qin, YQ ;

Labruyere, J ;

Nemmers, B ;

Olney, JW .

DEVELOPMENTAL BRAIN RESEARCH, 2005, 155 (01) :1-13

← 1 2 3 4 →