Pregnane steroids from the Vietnamese octocoral Carijoa riisei

被引：7

作者：

Nam Nguyen Hoai ^{[1
]}

Huong Nguyen Thi ^{[1
]}

Hanh Tran Thi Hong ^{[1
]}

Thanh Nguyen Van ^{[1
]}

Cuong Nguyen Xuan ^{[1
,2
]}

Thung Do Cong ^{[3
]}

Kiem Phan Van ^{[1
]}

Minh Chau Van ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

[2] VAST, Grad Univ Sci & Technol, Hanoi, Vietnam

[3] VAST, Inst Marine Environm & Resources, Haiphong, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 20期

关键词：

Carijoa riisei; Clavulariidae; octocoral; pregnane; steroid; SOFT CORAL; POLYOXYGENATED STEROIDS;

D O I：

10.1080/14786419.2017.1324964

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Six pregnane steroids including one new compound namely 15 beta-hydroxypregna- 4,20-dien-3-one (1), were isolated and structurally elucidated from the octocoral Carijoa riisei. The cytotoxic activity against a panel of eight human cancer cell lines of isolated compounds was also evaluated by SRB method. As the results, 18-acetoxypregna1,4,20-trien-3-one (5) showed significant cytotoxicity against all the tested cell lines with the IC50 values from 22.29 +/- 1.47 to 48.73 +/- 3.93 mu M, whereas 15 beta-acetoxypregna-1,4,20-trien-3-one (3) and 20R-acetoxypregna-1,4-dien-3-one (6) only exhibited weak effect on KB cell line with IC50 values of 93.62 +/- 7.32 and 71.38 +/- 5.45 mu M, respectively.

引用

页码：2435 / 2440

页数：6

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