Bioreductive activation and drug chaperoning in cobalt pharmaceuticals

被引：172
作者：
Hall, Matthew D.
Failes, Timothy W.
Yamamoto, Natsuho
Hambley, Trevor W. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia
[2] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA
来源：
DALTON TRANSACTIONS | 2007年 / 36卷 / 36期
关键词：
D O I：
10.1039/b707121c
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The potential for cobalt(III) complexes in medicine, as chaperones of bioactive ligands, and to target tumours through bioreductive activation, has been examined over the past 20 years. Despite this, chemical properties such as reduction potential and carrier ligands required for optimal tumour targeting and drug delivery have not been optimised. Here we review the chemistry of cobalt( III) drug design, and recent developments in the understanding of the cellular fate of these drugs.
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收藏
页码：3983 / 3990
页数：8
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