Synthesis and applications of 3-[6-(hydroxymethyl)pyridin-2-yl]-1,1′-bi-2-naphthols or 3,3′-bis[6-(hydroxymethyl)pyridin-2-yl]-1,1′-bi-2-naphthols

被引：10
|
作者：
Ma, Li [1 ]
Jin, Rin-Zhe [1 ]
Lue, Guang-Hua [1 ]
Bian, Zhen [1 ]
Ding, Meng-Xian [1 ]
Gao, Lian-Xun [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2007年 / 16期
关键词：
pyridin-2-ylmethanol; BINOL; Suzuki cross-coupling reaction; asymmetric catalysis;
D O I：
10.1055/s-2007-983787
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new 1,1'-bi-2-naphthol (BINOL) derived ligands, 3-[6-(hydroxymethyl)pyridin-2-yl]-BINOLs or 3,3'-bis[6(hydroxymethyl)pyridin-2-yl]-BINOLs, bearing one or two chiral pyridinylmetlianols attached to a binaphthyl skeleton, have been synthesized using the Suzuki cross-coupling reaction. The resulting compounds have been used as ligands in the enantioselective addition of diethylzinc to aldehydes; the products were obtained with up to 96% ee.
引用
收藏
页码：2461 / 2470
页数：10
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