Successful Treatment of Kaposiform Hemangioendothelioma With Everolimus

被引：41

作者：

Uno, Teruaki ^{[1
]}

Ito, Shuichi ^{[2
]}

Nakazawa, Atsuko ^{[3
]}

Miyazaki, Osamu ^{[4
]}

Mori, Tetsuya ^{[1
]}

Terashima, Keita ^{[1
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Setagaya Ku, Tokyo, Japan

[2] Natl Ctr Child Hlth & Dev, Div Nephrol & Rheumatol, Setagaya Ku, Tokyo, Japan

[3] Natl Ctr Child Hlth & Dev, Dept Pathol, Setagaya Ku, Tokyo, Japan

[4] Natl Ctr Child Hlth & Dev, Dept Radiol, Setagaya Ku, Tokyo, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2015年 / 62卷 / 03期

关键词：

Kasabach-Merritt phenomenon; mTOR; rapamycin; sirolimus; vascular tumor; SIROLIMUS; EFFICACY; SAFETY;

D O I：

10.1002/pbc.25241

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is currently no consensus on the second-line management of Kaposiform hemangioendothelioma (KHE) that was resistant to prednisolone and vincristine. We described an eight-year-old male with KHE in the right femur that was resistant to prednisolone, vincristine and propranolol. Everolimus, an inhibitor of mammalian target of rapamycin (mTOR) at the dosage of 0.1mg/kg/day, successfully decreased the tumor size and controlled the symptoms. Everolimus should be further studied as an alternative agent to sirolimus in the management of KHE. Pediatr Blood Cancer 2015;62:536-538. (c) 2014 Wiley Periodicals, Inc.

引用

页码：536 / 538

页数：3

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