Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent

被引：58

作者：

Arai, Masayoshi ^{[1
]}

Sobou, Mari ^{[1
]}

Vilcheze, Catherine ^{[2
]}

Baughn, Anthony ^{[2
]}

Hashizume, Hiroyuki ^{[3
]}

Pruksakorn, Patamaporn ^{[1
]}

Ishida, Shunsuke ^{[1
]}

Matsumoto, Makoto ^{[3
]}

Jacobs, William R., Jr. ^{[2
]}

Kobayashi, Motomasa ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Albert Einstein Coll Med, Howard Hughes Med Inst, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[3] Otsuka Pharmaceut Co Ltd, Microbiol Res Inst, Kawaguchi, Tokushima 7710192, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 14期

关键词：

halicyclamine; marine sponge; anti-Mycobacterium tuberculosis; dormant; hypoxia;

D O I：

10.1016/j.bmc.2008.05.061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the course of our search for anti-microbial agents against dormant Mycobacterium tuberculosis, halicyclamine A was re-discovered as a lead for anti-tuberculosis agent from a marine sponge of Haliclona sp. on the guidance of the constructed bioassay. Halicyclamine A showed growth inhibition against Mycobacterium smegmatis, Mycobacterium bovis BCG, and M. tuberculosis H37Ra with MICs in the range of 1.0-5.0 mu g/ml under both aerobic condition and hypoxic condition inducing dormant state. The growth-inhibitory activity of halicyclamine A was bactericidal, and halicyclamine A did not exhibit cross-resistance with the currently used anti-tuberculosis drugs of isoniazid, ethambutol, rifampicin, and streptomycin. Halicyclamine A has been isolated originally as one of the active constituents inhibiting inosine 5'-monophosphate dehydrogenase (IMPDH). Then, in order to elucidate action-mechanism of halicyclamine A, we prepared IMPDH over-expressing strains of M. smegmatis. However, IMPDH was not target for halicyclamine A, because halicyclamine A showed same MIC value against the wild-type M. smegmatis and IMPDH over-expressing strains. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6732 / 6736

页数：5

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