Gut Microbiota Regulation of AHR Signaling in Liver Disease

被引：12

作者：

Wang, Baohong ^{[1
,2
,3
]}

Zhou, Ziyuan ^{[1
]}

Li, Lanjuan ^{[1
,2
,3
,4
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Natl Clin Res Ctr Infect Dis,Sch Med,State Key La, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Peoples R China

[2] Chinese Acad Med Sci, Res Unit Infect Dis, Hangzhou 310022, Peoples R China

[3] Chinese Acad Med Sci, Res Unit Microecol, Hangzhou 310022, Peoples R China

[4] Jinan Microecol Biomed Shangdong Lab, Jinan 250021, Peoples R China

来源：

BIOMOLECULES | 2022年 / 12卷 / 09期

基金：

中国国家自然科学基金;

关键词：

liver disease; gut microbiota; aryl hydrocarbon receptor; tryptophan; ARYL-HYDROCARBON RECEPTOR; TRYPTOPHAN-METABOLISM; T-CELLS; ACTIVATION; MICE; EXPRESSION; HEALTH; IDENTIFICATION; HEPATOCYTES; SENSITIZES;

D O I：

10.3390/biom12091244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liver health plays a vital role in human health and disease. Emerging evidence has shown the importance of the aryl hydrocarbon receptor (AHR) in liver diseases such as alcoholic liver disease, fatty liver disease, and liver failure. As a ligand-activated transcription factor, AHR can be activated by endogenous ligands of microbial metabolites such as tryptophan (Trp), kynurenine (Kyn) or indole derivatives locally or distantly. However, the therapeutic effects of the gut microbiota-regulated AHR pathway remain to be clarified. In this review, we summarize recent progress and examine the role of AHR signaling as a target for gut microbiota intervention in liver diseases. The focus on AHR signaling will identify a promising target in the gut microbiota for better understanding and therapeutic opportunities in liver diseases.

引用

页数：16

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