Multiple faces of pulmonary large cell neuroendocrine carcinoma: update with a focus on practical approach to diagnosis

被引：47

作者：

Baine, Marina K. ^{[1
]}

Rekhtman, Natasha ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10065 USA

来源：

TRANSLATIONAL LUNG CANCER RESEARCH | 2020年 / 9卷 / 03期

关键词：

Differential diagnosis; large cell neuroendocrine carcinoma (LCNEC); molecular profile; treatment; LUNG-CANCER; PROGNOSTIC-SIGNIFICANCE; DIFFERENTIAL-DIAGNOSIS; ADJUVANT CHEMOTHERAPY; CLINICAL-FEATURES; GRADE; TUMORS; NEOPLASMS; ADENOCARCINOMA; CLASSIFICATION;

D O I：

10.21037/tlcr.2020.02.13

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pulmonary large cell neuroendocrine carcinoma (LCNEC)is a rare and aggressive malignancy that is strongly linked to smoking and notoriously difficult to diagnose and treat. Recent molecular data reveal that it represents a biologically heterogeneous group of tumors, characterized by morphologic and genomic diversity that straddles small cell and non-small cell lung carcinomas (NSCLCs), and in a minority of cases atypical carcinoids. This review provides an update on recent molecular and clinical developments in LCNEC with the main focus on practical approach to pathologic diagnosis using illustrative examples of the main differential diagnostic considerations.

引用

页码：860 / 878

页数：19

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