Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation

被引:1
作者
Mojtahedzadeh, Mojtaba [1 ,2 ]
Etezadi, Farhad [2 ]
Pourmand, Gholamreza [3 ]
Abrandabadi, Amir Hossein Najafi [2 ]
Motaharinia, Javad [1 ]
机构
[1] Univ Tehran Med Sci, Dept Pharmacotherapy, Fac Pharm, Tehran, Iran
[2] Univ Tehran Med Sci, Sina Hosp, Dept Anesthesiol & Crit Care, Tehran, Iran
[3] Univ Tehran Med Sci, Urol Res Ctr, Tehran, Iran
来源
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2017年 / 16卷 / 04期
关键词
Hypertonic saline; Deceased donor; Kidney transplantation; Delayed graft function; Neutrophil gelatinase-associated lipocalin and interleukin 18; ISCHEMIA-REPERFUSION INJURY; CONGESTIVE-HEART-FAILURE; HIGH-DOSE FUROSEMIDE; HEMORRHAGIC-SHOCK; IN-VIVO; ISCHEMIA/REPERFUSION; RESUSCITATION; EXPRESSION; PERFUSION;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Ischemia reperfusion injury (IRI) is one of the main causes of delayed graft function (DGF) in deceased-donor kidney transplantation (DDKT). Evidences suggest that hypertonic saline (HS) has beneficial effects on IRI. The objective of the present study is to determine the effect of intraoperative HS, on graft function and urinary biomarkers of interleukin 18 (IL-18) and neutrophil gelatinase-associated lipocalin (NGAL), in patients with DDKT. The design of the study is a randomized, open-label, pilot trial in patients with DDKT. The intervention of the study is administration of 4 mL/kg HS, 5% before graft reperfusion. The primary endpoint was DGF. Fifty-eight (58) adult patients were randomized (HS, n = 32; control, n = 26). There were no significant differences between the two groups in terms of recipient, donor, and transplant characteristics. The rate of DGF was 20% in the HS group compared with 31.8% in the control group (Relative risk 0.63; 95% CI 0.23-1.67; P = 0.36). Serial serum creatinine in the first two days after surgery in addition to urine volumes during the first day after transplantation was significantly different in the HS group (P = 0.05). The urinary NGAL and IL-18 were significantly lower in HS vs. control, at 24 h after transplantation (P = 0.05). The frequency of adverse reactions was similar between groups. This study did not show any significant benefits from HS administration immediately before allograft reperfusion in terms of reducing DGF, serum creatinine at hospital discharge or length of hospital stay in deceased-donor kidney transplant patients.
引用
收藏
页码:1583 / 1592
页数:10
相关论文
共 26 条
  • [1] Andre Mark, 2014, Clin Transpl, P1
  • [2] Hypertonic saline prevents inflammation, injury, and impaired intestinal transit after gut ischemia/reperfusion by inducing heme oxygenase 1 enzyme
    Attuwaybi, B
    Kozar, RA
    Gates, KS
    Moore-Olufemi, S
    Sato, N
    Weisbrodt, NW
    Moore, FA
    [J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2004, 56 (04): : 749 - 758
  • [3] Beneficial effects of hyperosmotic perfusion in the myocardium after ischemia/reperfusion injury in isolated rat hearts
    Cao, Yong
    Wang, Lie
    Chen, Hong
    Lv, Zhiqian
    [J]. REVISTA BRASILEIRA DE CIRURGIA CARDIOVASCULAR, 2013, 28 (01): : 54 - 60
  • [4] Chen LB, 2003, ACTA PHARMACOL SIN, V24, P1077
  • [5] Sample size calculations for pilot randomized trials: a confidence interval approach
    Cocks, Kim
    Torgerson, David J.
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2013, 66 (02) : 197 - 201
  • [6] Hypertonic saline with furosemide for the treatment of acute congestive heart failure: A systematic review and meta-analysis
    Gandhi, Sumeet
    Mosleh, Wassim
    Myers, Robert B. H.
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 173 (02) : 139 - 145
  • [7] Halawa A, 2011, ANN TRANSPL, V16, P90
  • [8] Sodium chloride inhibits cytokine production by lipopolysaccharide-stimulated human neutrophils and mononuclear cells
    Hatanaka, Elaine
    Shimomi, Flavia Mammy
    Curi, Rui
    Campa, Ana
    [J]. SHOCK, 2007, 27 (01): : 32 - 35
  • [9] Kolsen-Petersen JA, 2004, ACTA ANAESTH SCAND, V150, P239
  • [10] Effect of Hypertonic Versus Isotonic Saline Resuscitation on Heme Oxygenase-1 Expression in Visceral Organs Following Hemorrhagic Shock in Rats
    Lu Yuan Qiang
    Gu Lin Hui
    Jiang Jiu Kun
    Mou Han Zhou
    [J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2013, 26 (08) : 684 - 688