ARTS, the unusual septin: structural and functional aspects

被引：24

作者：

Mandel-Gutfreund, Yael ^{[2
]}

Kosti, Idit ^{[2
]}

Larisch, Sarit ^{[1
]}

机构：

[1] Univ Haifa, Fac Nat Sci, Dept Biol, Cell Death Res Lab, IL-31905 Haifa, Israel

[2] Technion Israel Inst Technol, Fac Biol, Computat Mol Biol Lab, IL-31096 Haifa, Israel

来源：

BIOLOGICAL CHEMISTRY | 2011年 / 392卷 / 8-9期

基金：

以色列科学基金会;

关键词：

apoptosis; ARTS; mitochondria; Sept4; tumor suppressor protein; XIAP; SERINE-PROTEASE OMI/HTRA2; INTRON RETENTION EVENTS; CASPASE ACTIVATION; MAMMALIAN SEPTINS; MITOCHONDRIAL SEPTIN; PROMOTES APOPTOSIS; DISTINCT DOMAINS; BUDDING YEAST; IAP PROTEINS; CELL-DEATH;

D O I：

10.1515/BC.2011.089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human Septin 4 gene (Sept4) encodes two major protein isoforms; Sept4_i1 (H5/PNUTL2) and Sept4_i2/ARTS. Septins have been traditionally studied for their role in cytokinesis and their filament-forming abilities, but subsequently have been implicated in diverse functions, including membrane dynamics, cytoskeletal reorganization, vesicle trafficking, and tumorigenesis. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). These features distinguish ARTS from any other known human septin family member. This review compares the structural and functional properties of ARTS with other septins. In addition, it describes how a combination of two distinct promoters, differential splicing, and intron retention leads to the generation of two different Sept4 variants with diverse biological activity.

引用

页码：783 / 790

页数：8

共 88 条

[1] Quantitative analysis of pathways controlling extrinsic apoptosis in single cells [J].

Albeck, John G. ;

Burke, John M. ;

Aldridge, Bree B. ;

Zhang, Mingsheng ;

Lauffenburger, Douglas A. ;

Sorger, Peter K. .

MOLECULAR CELL, 2008, 30 (01) :11-25

[2]

Bangs P, 2000, DEV DYNAM, V218, P68, DOI 10.1002/(SICI)1097-0177(200005)218:1<68::AID-DVDY6>3.0.CO

[3]

2-9

[4] Splicing in action: assessing disease causing sequence changes [J].

Baralle, D ;

Baralle, M .

JOURNAL OF MEDICAL GENETICS, 2005, 42 (10) :737-748

[5] Targeting metastable coiled-coil domains by computational design [J].

Barth, Patrick ;

Schoeffler, Allyn ;

Alber, Tom .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (36) :12038-12044

[6] Phosphatidylinositol-4,5-bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization [J].

Bertin, Aurelie ;

McMurray, Michael A. ;

Thai, Luong ;

Garcia, Galo, III ;

Votin, Violet ;

Grob, Patricia ;

Allyn, Theresa ;

Thorner, Jeremy ;

Nogales, Eva .

JOURNAL OF MOLECULAR BIOLOGY, 2010, 404 (04) :711-731

[7]

BORNSTEIN B, 2011, APOPTOSIS 0622

[8] HIGHLY ORDERED RING OF MEMBRANE-ASSOCIATED FILAMENTS IN BUDDING YEAST [J].

BYERS, B ;

GOETSCH, L .

JOURNAL OF CELL BIOLOGY, 1976, 69 (03) :717-721

[9] Molecular dissection of a yeast septin: Distinct domains are required for septin interaction, localization, and function [J].

Casamayor, A ;

Snyder, M .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (08) :2762-2777

[10]

CESARIO MM, 1994, J CELL SCI, V107, P561

← 1 2 3 4 5 6 7 8 9 →