Sea urchin sperm cation-selective channels directly modulated by cAMP

被引：24
作者：
Sánchez, D
Labarca, P
Darszon, A
机构：
[1] Univ Nacl Autonoma Mexico, Inst Biotecnol, Dept Genet & Fisiol Mol, Cuernavaca 62250, Morelos, Mexico
[2] Ctr Estudios Cient, Valdivia, Chile
来源：
FEBS LETTERS | 2001年 / 503卷 / 01期
关键词：
speract; cAMP; hyperpolarization-activated cyclic nucleotide-gated channel; sperm; sea urchin;
D O I：
10.1016/S0014-5793(01)02713-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Components of the sea urchin outer egg jelly layer such as speract drastically change second messenger levels and membrane permeability in sperm. Ion channels are deeply involved in the sperm-egg dialogue in sea urchin and other species. Yet, due to the small size of sperm, studies of ion channels and their modulation by second messengers in sperm are scarce. In this report we offer the first direct evidence that cation-selective channels upwardly regulated by cAMP operate in sea urchin sperm. Due to their poor selectivity among monovalent cations, channel activation in seawater could contribute to sperm membrane repolarization during the speract response. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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收藏
页码：111 / 115
页数：5
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