Circulating tumor cells as a "real-time liquid biopsy": Recent advances and the application in ovarian cancer

被引：12
作者：
Jou, Hei-Jen [1 ,2 ,3 ,4 ]
Ling, Pei-Ying [1 ]
Hsu, Heng-Tung [3 ]
机构：
[1] Taiwan Adventist Hosp, Dept Obstet & Gynecol, 424,Sec 2,Bade Rd, Taipei 10556, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Taipei, Taiwan
[3] Natl Yang Ming Chiao Tung Univ, Int Coll Semicond Technol, Hsinchu, Taiwan
[4] Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, Taipei, Taiwan
来源：
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY | 2022年 / 61卷 / 01期
关键词：
Circulating tumor cells; Liquid biopsy; Microfluidics; Ovarian cancer; EPITHELIAL OVARIAN; BREAST-CANCER; MOLECULAR CHARACTERIZATION; EPCAM EXPRESSION; PREDICTIVE-VALUE; BIOMARKERS; DIAGNOSIS; SURVIVAL; BLOOD; TRIAL;
D O I：
10.1016/j.tjog.2021.11.008
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Even with the latest advances in technology, the treatment of ovarian cancer remains a big challenge because it is typically diagnosed at advanced stage, is prone to early relapse in spite of aggressive treatment and has an extremely poor prognosis. Circulating tumor cells (CTCs) can be used as a non-invasive "real-time liquid biopsy", which has shown the value of diagnosis, assessment of prognosis and chemoresistance, and detection of small residual tumors on ovarian cancer. This review article provides an overview on recent research on CTCs in ovarian cancer, with special focus on the clinical application of CTC tests. (C) 2022 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
引用
收藏
页码：34 / 39
页数：6
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