The expression of SEIPIN in the mouse central nervous system

被引：9

作者：

Liu, Xiaoyun ^{[1
]}

Xie, Beibei ^{[2
]}

Qi, Yanfei ^{[1
]}

Du, Ximing ^{[1
]}

Wang, Shaoshi ^{[3
]}

Zhang, Yumei ^{[4
]}

Paxinos, George ^{[5
,6
]}

Yang, Hongyuan ^{[1
]}

Liang, Huazheng ^{[5
,6
]}

机构：

[1] Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW, Australia

[2] Linyi Hosp, Dept Gynecol & Obstet, Linyi, Shangdong Provi, Peoples R China

[3] Shanghai 1 Peoples Hosp, Dept Neurol, Shanghai, Peoples R China

[4] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China

[5] Neurosci Res Australia, 139 Barker St, Randwick, NSW 2031, Australia

[6] Univ New South Wales, Sch Med Sci, Kensington, NSW, Australia

来源：

BRAIN STRUCTURE & FUNCTION | 2016年 / 221卷 / 08期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

SEIPIN; Brain; Supraspinal projection; Spinal cord; Seipinopathy; Motor control; CONGENITAL GENERALIZED LIPODYSTROPHY; ENDOPLASMIC-RETICULUM STRESS; SILVER-SYNDROME; MOTOR NEUROPATHY; MUTATION; BSCL2; GENE; PHENOTYPE; PROTEIN; NEURONS;

D O I：

10.1007/s00429-015-1151-3

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Immunohistochemical staining was used to investigate the expression pattern of SEIPIN in the mouse central nervous system. SEIPIN was found to be present in a large number of areas, including the motor and somatosensory cortex, the thalamic nuclei, the hypothalamic nuclei, the mesencephalic nuclei, some cranial motor nuclei, the reticular formation of the brainstem, and the vestibular complex. Double labeling with NeuN antibody confirmed that SEIPIN-positive cells in some nuclei were neurons. Retrograde tracer injections into the spinal cord revealed that SEIPIN-positive neurons in the motor and somatosensory cortex and other movement related nuclei project to the mouse spinal cord. The present study found more nuclei positive for SEIPIN than shown using in situ hybridization and confirmed the presence of SEIPIN in neurons projecting to the spinal cord. The results of this study help to explain the clinical manifestations of patients with Berardinelli-Seip congenital lipodystrophy (Bscl2) gene mutations.

引用

页码：4111 / 4127

页数：17

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