Hybrid mass spectrometers for tandem mass Spectrometry

被引：75

作者：

Glish, Gary L. ^{[1
]}

Burinsky, David J. ^{[2
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] GlaxoSmithKline, Res Triangle Pk, NC USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2008年 / 19卷 / 02期

关键词：

D O I：

10.1016/j.jasms.2007.11.013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mass spectrometers that use different types of analyzers for the first and second stages of mass analysis in tandem mass spectrometry (MS/MS) experiments are often referred to as "hybrid" mass spectrometers. The general goal in the design of a hybrid instrument is to combine different performance characteristics offered by various types of analyzers into one mass spectrometer. These performance characteristics may include mass resolving power, the ion kinetic energy for collision-induced dissociation, and speed of analysis. This paper provides a review of the development of hybrid instruments over the last 30 years for analytical applications.

引用

页码：161 / 172

页数：12

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