CRISPR-Based Technologies: Impact of RNA-Targeting Systems

被引：122

作者：

Terns, Michael P. ^{[1
,2
,3
]}

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] Univ Georgia, Dept Genet, Athens, GA 30602 USA

[3] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA

来源：

MOLECULAR CELL | 2018年 / 72卷 / 03期

关键词：

NUCLEIC-ACID DETECTION; CAS IMMUNITY; CMR COMPLEX; CSM COMPLEX; THERMUS-THERMOPHILUS; CRYSTAL-STRUCTURE; DNA CLEAVAGE; PROTEIN; DEGRADATION; RECOGNITION;

D O I：

10.1016/j.molcel.2018.09.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA-targeting CRISPR-Cas systems, such as those employing the RNA-guided Cas9 or Cas12 endonucleases, have revolutionized our ability to predictably edit genomes and control gene expression. Here, I summarize information on RNA-targeting CRISPR-Cas systems and describe recent advances in converting them into powerful and programmable RNA-binding and cleavage tools with a wide range of novel and important biotechnological and biomedical applications.

引用

页码：404 / 412

页数：9

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