The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing

被引：248

作者：

Rani, Sweta ^{[1
]}

Ritter, Thomas ^{[1
]}

机构：

[1] Natl Univ Ireland, Coll Med Nursing & Hlth Sci, Sch Med, Regenerat Med Inst REMEDI, Galway, Galway, Ireland

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 27期

基金：

爱尔兰科学基金会;

关键词：

cell-free; extracellular vesicles; mesenchymal stem cells; nanoparticles; wound healing; MESENCHYMAL STEM-CELLS; DRUG-DELIVERY SYSTEMS; EXTRACELLULAR VESICLES; ENHANCE ANGIOGENESIS; GROWTH-FACTORS; T-CELLS; MICRORNA; MICROVESICLES; RNA; ASSOCIATION;

D O I：

10.1002/adma.201504009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Wound healing is a complex process and often delayed in patients with underlying chronic conditions. The cost of wound care is a significant burden to the society, warranting new techniques to prompt wound healing. Several studies have reported on the beneficial effects of mesenchymal stem cells (MSCs) function in recruiting host cells, releasing secretory factors and matrix proteins thereby increasing wound heal. These secrete bioactive trophic factors from MSCs also includes extracellular vesicles (EVs) or exosomes. Recent studies have shown that EVs are one of the key secretory products of MSCs mediating cell-to-cell communication to enhance wound healing. Current knowledge related to the potential use of EVs in wound healing is reviewed and the promising future for EVs - a naturally secreted nanoparticle - as an alternative to cell-based therapy is discussed.

引用

页码：5542 / 5552

页数：11

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