Study on free radicals and pancreatic fibrosis - Pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor

被引:49
作者
Matsumura, N
Ochi, K
Ichimura, M
Mizushima, T
Harada, H
Harada, M
机构
[1] Okayama Univ, Sch Med, Dept Internal Med 2, Okayama 7008558, Japan
[2] Okayama Univ, Sch Med, Dept Lab Med, Okayama 7008558, Japan
[3] Okayama Univ, Sch Med, Fac Hlth Sci, Okayama 7008558, Japan
关键词
free radicals; pancreatic fibrosis; diethyldithiocarbamate; lipid peroxide; superoxide dismutase;
D O I
10.1097/00006676-200101000-00009
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The exact mechanisms of the development of pancreatic fibrosis are still unknown. To clarify the relationship between pancreatic fibrosis and free radicals, the effect of the administration of a superoxide dismutase (SOD) inhibitor, diethyldithiocarbamate (DDC), on pancreatic fibrosis in rats was studied. A single intraperitoneal injection of 500 mg/kg of DDC significantly reduced SOD activity and significantly increased lipid peroxidation products in the pancreas, showing no histologic changes of inflammation or necrosis. Repeated administration of 500 mg/kg DDC, twice a week, caused inter- and intralobular fibrosis with atrophy of acinar cells in the pancreas for at least 2 weeks without fibrosis of the liver and kidney. Administration of allopurinol showed preventive effects against DDC-induced pancreatic fibrosis. In conclusion, repeated administration of DDC, which caused pancreatic fibrosis, is a new experimental model of pancreatic fibrosis from the viewpoint of oxidative stress.
引用
收藏
页码:53 / 57
页数:5
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