Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study

被引：109

作者：

Companys, Judit ^{[1
,2
]}

Gosalbes, Maria Jose ^{[3
,4
]}

Pla-Paga, Laura ^{[1
,2
]}

Calderon-Perez, Lorena ^{[1
,2
]}

Llaurado, Elisabet ^{[2
]}

Pedret, Anna ^{[1
,2
]}

Valls, Rosa Maria ^{[1
,2
]}

Jimenez-Hernandez, Nuria ^{[3
,4
]}

Sandoval-Ramirez, Berner Andree ^{[2
]}

del Bas, Josep Maria ^{[1
]}

Caimari, Antoni ^{[5
]}

Rubio, Laura ^{[6
]}

Sola, Rosa ^{[1
,2
,7
]}

机构：

[1] Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain

[2] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain

[3] Fdn el Fomento Invest Sanitaria & Biomed, Valencia 46020, Spain

[4] CIBER Epidemiol & Salud Publ, Madrid 28029, Spain

[5] Ctr Tecnol Catalunya, Eurecat, Biotechnol Area, Reus 43204, Spain

[6] Univ Lleida, Escola Tecn Super Engn Agr, Agrotecnio Ctr, XaRTA TPV,Food Technol Dept, Avda Alcalde Rovira Roure 191, Catalonia 25198, Spain

[7] Hosp Univ St Joan Reus, Reus 43201, Spain

来源：

NUTRIENTS | 2021年 / 13卷 / 06期

关键词：

obesity; gut microbiota; dietary intake; saturated fatty acids; OBESITY; WEIGHT; POPULATION; ALIGNMENT;

D O I：

10.3390/nu13062032

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.

引用

页数：17

共 39 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].

ALTSCHUL, SF ;

GISH, W ;

MILLER, W ;

MYERS, EW ;

LIPMAN, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410

[2]

[Anonymous], WHO OBESITY OVERWEIG

[3] Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations JACC State-of-the-Art Review [J].

Astrup, Arne ;

Magkos, Faidon ;

Bier, Dennis M. ;

Brenna, J. Thomas ;

de Oliveira Otto, Marcia C. ;

Hill, James O. ;

King, Janet C. ;

Mente, Andrew ;

Ordovas, Jose M. ;

Volek, Jeff S. ;

Yusuf, Salim ;

Krauss, Ronald M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 76 (07) :844-857

[4] Differences in gut microbiota composition between obese and lean children: a cross-sectional study [J].

Bervoets, Liene ;

Van Hoorenbeeck, Kim ;

Kortleven, Ineke ;

Van Noten, Caroline ;

Hens, Niel ;

Vael, Carl ;

Goossens, Herman ;

Desager, Kristine N. ;

Vankerckhoven, Vanessa .

GUT PATHOGENS, 2013, 5

[5]

Best D. J., 1975, Applied Statistics, V24, P377, DOI 10.2307/2347111

[6]

Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/nmeth.3869, 10.1038/NMETH.3869]

[7] Diet rapidly and reproducibly alters the human gut microbiome [J].

David, Lawrence A. ;

Maurice, Corinne F. ;

Carmody, Rachel N. ;

Gootenberg, David B. ;

Button, Julie E. ;

Wolfe, Benjamin E. ;

Ling, Alisha V. ;

Devlin, A. Sloan ;

Varma, Yug ;

Fischbach, Michael A. ;

Biddinger, Sudha B. ;

Dutton, Rachel J. ;

Turnbaugh, Peter J. .

NATURE, 2014, 505 (7484) :559-+

[8] Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women [J].

Dugas, Lara R. ;

Bernabe, Beatriz Penalver ;

Priyadarshini, Medha ;

Fei, Na ;

Park, Seo Jin ;

Brown, Laquita ;

Plange-Rhule, Jacob ;

Nelson, David ;

Toh, Evelyn C. ;

Gao, Xiang ;

Dong, Qunfeng ;

Sun, Jun ;

Kliethermes, Stephanie ;

Gottel, Neil ;

Luke, Amy ;

Gilbert, Jack A. ;

Layden, Brian T. .

SCIENTIFIC REPORTS, 2018, 8

[9] The role of the gut microbiota in nutrition and health [J].

Flint, Harry J. ;

Scott, Karen P. ;

Louis, Petra ;

Duncan, Sylvia H. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2012, 9 (10) :577-589

[10] Metatranscriptomic analysis to define the Secrebiome, and 16S rRNA profiling of the gut microbiome in obesity and metabolic syndrome of Mexican children [J].

Gallardo-Becerra, Luigui ;

Cornejo-Granados, Fernanda ;

Garcia-Lopez, Rodrigo ;

Valdez-Lara, Alejandra ;

Bikel, Shirley ;

Canizales-Quinteros, Samuel ;

Lopez-Contreras, Blanca E. ;

Mendoza-Vargas, Alfredo ;

Nielsen, Henrik ;

Ochoa-Leyva, Adrian .

MICROBIAL CELL FACTORIES, 2020, 19 (01)

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