Background Urological dysfunction in patients with multiple system atrophy (MSA) is one of the main manifestations of autonomic failure. Urodynamic examination is clinically relevant since underlying pathophysiology of lower urinary tract (LUT) dysfunction can be variable. Objective Evaluation of the pathophysiology of urological symptoms and exploration of differences in urodynamic patterns of LUT dysfunction between MSA-P and MSA-C. Methods Retrospective study of patients with possible and probable MSA who were referred for urodynamic studies between 2004 and 2019. Demographic data, medical history, physical examination and urodynamic studies assessing storage and voiding dysfunction were obtained. Results Seventy-four patients were included in this study (MSA-P 64.9% n = 48; median age 62.5 (IQR 56.8-70) years). Detrusor overactivity during filling phase was noted in 58.1% (n = 43) of the patients. In the voiding phase, detrusor sphincter dyssynergia and detrusor underactivity were observed in 24.6% (n = 17) and in 62.1% (n = 41) of the patients, respectively. A postmicturition residual volume of over 100 ml was present in 71.4% (n = 50) of the patients. Comparison of MSA subtypes showed weaker detrusor contractility in MSA-P compared to MSA-C [pdetQmax 26.2 vs. 34.4 cmH20, P = 0.04]. In 56.2% (n = 41) of patients pathophysiology of LUT dysfunction was deemed to be neurogenic and consistent with the diagnosis of MSA. In 35.6% (n = 26) urodynamic pattern suggested other urological co-morbidities. Conclusion Urodynamic evaluation is an important tool to analyze the pattern of LUT dysfunction in MSA. Impaired detrusor contractility was seen more in MSA-P which needs to be investigated in further studies.
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Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Gilman, S.
Wenning, G. K.
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Med Univ Innsbruck, Innsbruck, AustriaUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Wenning, G. K.
Low, P. A.
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Mayo Clin Rochester, Rochester, MN USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Low, P. A.
Brooks, D. J.
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Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London SW7 2AZ, England
Univ London Imperial Coll Sci Technol & Med, Dept Clin Neurosci, London SW7 2AZ, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Brooks, D. J.
Mathias, C. J.
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Univ London Imperial Coll Sci Technol & Med, Neurovasc Med Pickering Unit Fac Med, London SW7 2AZ, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Mathias, C. J.
Trojanowski, J. Q.
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Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Trojanowski, J. Q.
Wood, N. W.
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Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Wood, N. W.
Colosimo, C.
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Univ Roma La Sapienza, Dept Neurol Sci, Rome, ItalyUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Colosimo, C.
Duerr, A.
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Grp Hosp Pitie Salpetriere, INSERM, U289, Paris, FranceUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Duerr, A.
Fowler, C. J.
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Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Fowler, C. J.
Kaufmann, H.
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NYU, Sch Med, New York, NY USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Kaufmann, H.
Klockgether, T.
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Univ Hosp Bonn, Bonn, GermanyUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Klockgether, T.
Lees, A.
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Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Lees, A.
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Poewe, W.
Quinn, N.
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Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Quinn, N.
Revesz, T.
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Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Revesz, T.
Robertson, D.
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Vanderbilt Univ, Clin Res Ctr, Nashville, TN USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Robertson, D.
Sandroni, P.
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Mayo Clin Rochester, Rochester, MN USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Sandroni, P.
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Seppi, K.
Vidailhet, M.
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Univ Paris 06, Federat Neurol & INSERM, U679, F-75252 Paris 05, FranceUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
机构:
Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Gilman, S.
Wenning, G. K.
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h-index: 0
机构:
Med Univ Innsbruck, Innsbruck, AustriaUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Wenning, G. K.
Low, P. A.
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h-index: 0
机构:
Mayo Clin Rochester, Rochester, MN USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Low, P. A.
Brooks, D. J.
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h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London SW7 2AZ, England
Univ London Imperial Coll Sci Technol & Med, Dept Clin Neurosci, London SW7 2AZ, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Brooks, D. J.
Mathias, C. J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Neurovasc Med Pickering Unit Fac Med, London SW7 2AZ, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Mathias, C. J.
Trojanowski, J. Q.
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h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Trojanowski, J. Q.
Wood, N. W.
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Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Wood, N. W.
Colosimo, C.
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机构:
Univ Roma La Sapienza, Dept Neurol Sci, Rome, ItalyUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Colosimo, C.
Duerr, A.
论文数: 0引用数: 0
h-index: 0
机构:
Grp Hosp Pitie Salpetriere, INSERM, U289, Paris, FranceUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Duerr, A.
Fowler, C. J.
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h-index: 0
机构:
Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Fowler, C. J.
Kaufmann, H.
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NYU, Sch Med, New York, NY USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Kaufmann, H.
Klockgether, T.
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h-index: 0
机构:
Univ Hosp Bonn, Bonn, GermanyUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Klockgether, T.
Lees, A.
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机构:
Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Lees, A.
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Poewe, W.
Quinn, N.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Quinn, N.
Revesz, T.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Hosp Queen Sq, London, EnglandUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Revesz, T.
Robertson, D.
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h-index: 0
机构:
Vanderbilt Univ, Clin Res Ctr, Nashville, TN USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Robertson, D.
Sandroni, P.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin Rochester, Rochester, MN USAUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
Sandroni, P.
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机构:
Seppi, K.
Vidailhet, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Federat Neurol & INSERM, U679, F-75252 Paris 05, FranceUniv Michigan, Dept Neurol, Ann Arbor, MI 48109 USA