Lethal obesity associated with sodium valproate in a brain-injured patient

被引：1
作者：
Black, DN
Althoff, RR
Daye, K
Pelletier, CA
机构：
[1] Vermont State Hosp, Waterbury, VT 05671 USA
[2] Univ Vermont, Dept Neurol, Burlington, VT USA
[3] Univ Vermont, Dept Psychiat, Burlington, VT USA
来源：
COGNITIVE AND BEHAVIORAL NEUROLOGY | 2005年 / 18卷 / 02期
关键词：
appetite; orbitofrontal; valproate;
D O I：
10.1097/01.wnn.0000152204.71409.2e
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
A 34-year-old man developed posttraumatic epilepsy and a disinhibited orbitofrontal syndrome following severe head trauma at age 22. After an 11-year prison term marked by repeated impulsive aggression, he was transferred to a state psychiatric hospital. Replacement of phenytoin by valproic acid resulted in a 100-lb weight gain, exacerbation of sleep apnea, and right heart failure. Despite replacement of valproate with topiramate, he died of a cardiorespiratory arrest during a seizure. This case illustrates the potential risks associated with valproate therapy in the obese brain-damaged population.
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页码：98 / 101
页数：4
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