DNA Binding and Recognition of a CC Mismatch in a DNA Duplex by Water-Soluble Peptidocalix[4]arenes: Synthesis and Applications

被引：9
作者：
Alavijeh, Nahid S. [1 ]
Zadmard, Reza [1 ]
Balalaie, Saeed [2 ]
Alavijeh, Mohammad S. [3 ]
Soltani, Nima [4 ]
机构：
[1] Chem & Chem Engn Res Ctr Iran, POB 14335-186, Tehran 1496813151, Iran
[2] KN Toosi Univ Technol, Peptide Chem Res Ctr, POB 15875-4416, Tehran 1969764499, Iran
[3] Pharmidex Pharmaceut Serv Ltd, London W1S 1YH, England
[4] Sharif Univ Technol, Dept Chem, POB 11155-3516, Tehran 1458889694, Iran
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 19期
关键词：
PROTEIN; CALIXARENES; SPECIFICITY; DELIVERY; COMPLEX;
D O I：
10.1021/acs.orglett.6b01995
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Water-soluble peptidocalix[4]arenes were synthesized by the introduction of arginine-rich narrow groove binding residues at lower rims through solid-phase synthesis. The study of binding of these water-soluble bidentate ligands to well-matched and mismatched DNA duplexes by fluorescent titrations, ethidium bromide (EB) displacement assays, DNA-melting experiments, and circular dichroism (CD) analysis revealed a sequence-dependent groove-binding mechanism.
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收藏
页码：4766 / 4769
页数：4
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