DNA Binding and Recognition of a CC Mismatch in a DNA Duplex by Water-Soluble Peptidocalix[4]arenes: Synthesis and Applications

被引：9

作者：

Alavijeh, Nahid S. ^{[1
]}

Zadmard, Reza ^{[1
]}

Balalaie, Saeed ^{[2
]}

Alavijeh, Mohammad S. ^{[3
]}

Soltani, Nima ^{[4
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, POB 14335-186, Tehran 1496813151, Iran

[2] KN Toosi Univ Technol, Peptide Chem Res Ctr, POB 15875-4416, Tehran 1969764499, Iran

[3] Pharmidex Pharmaceut Serv Ltd, London W1S 1YH, England

[4] Sharif Univ Technol, Dept Chem, POB 11155-3516, Tehran 1458889694, Iran

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 19期

关键词：

PROTEIN; CALIXARENES; SPECIFICITY; DELIVERY; COMPLEX;

D O I：

10.1021/acs.orglett.6b01995

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Water-soluble peptidocalix[4]arenes were synthesized by the introduction of arginine-rich narrow groove binding residues at lower rims through solid-phase synthesis. The study of binding of these water-soluble bidentate ligands to well-matched and mismatched DNA duplexes by fluorescent titrations, ethidium bromide (EB) displacement assays, DNA-melting experiments, and circular dichroism (CD) analysis revealed a sequence-dependent groove-binding mechanism.

引用

页码：4766 / 4769

页数：4

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