Effect of melatonin supplementation in combination with neoadjuvant chemotherapy to miR-210 and CD44 expression and clinical response improvement in locally advanced oral squamous cell carcinoma: a randomized controlled trial

被引：21

作者：

Kartini, Diani ^{[1
]}

Taher, Akmal ^{[2
]}

Panigoro, Sonar Soni ^{[1
]}

Setiabudy, Rianto ^{[3
]}

Jusman, Sri Widia ^{[4
]}

Haryana, Sofia Mubarika ^{[5
]}

Abdullah, Murdani ^{[6
]}

Rustamadji, Primariadewi ^{[7
]}

Purwanto, Denni Joko ^{[8
]}

Sutandyo, Noorwati ^{[9
]}

Suroyo, Indrati ^{[10
]}

Siregar, Budi Harapan ^{[11
]}

Maruli, Haris ^{[11
]}

Sungkar, Saleha ^{[12
]}

机构：

[1] Univ Indonesia, Dr Cipto Mangunkusumo Natl Cent Gen Hosp, Fac Med, Oncol Div,Dept Surg, Jakarta 10430, Indonesia

[2] Univ Indonesia, Cipto Mangunkusumo Hosp, Fac Med, Dept Urol, Jakarta, Indonesia

[3] Univ Indonesia, Dr Cipto Mangunkusumo Natl Cent Gen Hosp, Fac Med, Dept Pharmacol & Therapeut, Jakarta, Indonesia

[4] Univ Indonesia, Dr Cipto Mangunkusumo Natl Cent Gen Hosp, Fac Med, Dept Biochem & Mol Genet, Jakarta, Indonesia

[5] Univ Gadjah Mada, Fac Med Publ Hlth & Nursing, Dept Histol & Cell Biol, Yogyakarta, Indonesia

[6] Dr Cipto Mangunkusumo Natl Cent Gen Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Jakarta, Indonesia

[7] Univ Indonesia, Cipto Mangunkusumo Hosp, Fac Med, Dept Pathol Anat, Jakarta, Indonesia

[8] Dharmais Hosp, Natl Canc Ctr, Dept Surg Oncol, Jakarta, Indonesia

[9] Dharmais Hosp, Natl Canc Ctr, Dept Hematol & Med Oncol, Jakarta, Indonesia

[10] Dr Cipto Mangunkusumo Natl Cent Gen Hosp, Dept Radiol, Jakarta, Indonesia

[11] Persahabatan Gen Hosp, Dept Surg, Oncol Div, Jakarta, Indonesia

[12] Univ Indonesia, Dr Cipto Mangunkusumo Natl Cent Gen Hosp, Fac Med, Dept Parasitol, Jakarta, Indonesia

来源：

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE | 2020年 / 32卷 / 01期

关键词：

CD44; Clinical Response; Melatonin; OSCC; Tumor residue percentage; CANCER; MECHANISMS; HEAD;

D O I：

10.1186/s43046-020-0021-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Squamous cell carcinoma of the oral cavity (OSCC) is the sixth most common malignancy. Surgery is mainstay treatment for oral cancers. Surgery in locally advanced OSCC presents many challenges primarily because the head and neck have critical structures that can be damaged by tumor or treatment. It is thought that neoadjuvant chemotherapy (NC) in locally advanced OSCC is able to shrink tumor size. Chemoresistancy is a problem due to hypoxic microenvironment characterized by increased expression of HIF-1 alpha. It is also regulated by miR-210 as well as increased expression of CD44 and CD133. Melatonin has a powerful antioxidant and oncostatic effects that are expected to improve tumor hypoxia and clinical response. Fifty patients with OSCC were included and randomized. miR-210 and CD44 expression were measured before and after intervention using qRT-PCR absolute quantification, and clinical response was evaluated according to RECIST 1.1 criteria. This study aims to determine the effect of melatonin in improving the clinical response of patients with locally advanced oral squamous cell carcinoma (OSCC) after neoadjuvant chemotherapy to miR-210 and CD44 expression. Results Melatonin administration reduced miR-210 levels but not significant (p = 0.767). CD44 expression also decreased in the melatonin group compared with placebo yet was not significant (p = 0.103). There was a decrease in the expression of miR-210 and CD44 followed by a decrease in the percentage of residual tumor but not significant (p = 0.114). Conclusion In OSCC, the addition of 20-mg melatonin to neoadjuvant chemotherapy (NC) reduced the expression of miR-210 and CD44 and decreased the percentage of tumor residue; however, no statistically significant result was observed.

引用

页数：7

共 31 条

[1] The potential therapeutic effect of melatonin on human ovarian cancer by inhibition of invasion and migration of cancer stem cells [J].