Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation

被引:33
作者
Fagundes, Felipe Leonardo [1 ]
Pereira, Quelita Cristina [1 ]
Zarricueta, Melina Luzzi [1 ]
dos Santos, Raquel de Cassia [1 ]
机构
[1] Sao Francisco Univ, Lab Pharmacol & Mol Biol, Post Grad Program Hlth Sci, Sch Med, BR-12916900 Braganca Paulista, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
malvidin; peptic ulcer; mice; anti-inflammatory activity; ISCHEMIA-REPERFUSION; GASTRIC-ULCER; INTESTINAL INFLAMMATION; MYOCARDIAL-INFARCTION; INJURY; ANTHOCYANINS; EXPRESSION; ETHANOL; MODELS; RATS;
D O I
10.3390/nu13103312
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Peptic ulcer episodes cause damage to the stomach and intestine, with inflammatory cell infiltration and oxidative stress as the main players. In this study, we investigated the potential of anthocyanidin malvidin for preventive and curative peptic ulcer treatment. The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy. Expression levels of oxidative and inflammatory genes were measured to investigate the mechanism of anthocyanin activity. At a dose of 5 mg.kg(-1), Malvidin prevented gastric ulcer induction by ethanol, NSAID and repaired the tissue after 6 days of IR. Moreover, the anthocyanidin accelerated the healing of acetic acid-induced ulcer, increased the gene expression of EGF and COX-1, and downregulated MMP-9. Anthocyanin treatment mitigated the effect of polypharmacy on inflammation and oxidative stress observed in the intestine. Additionally, the compound downregulated cytokine expression and TLR4 and upregulated HMOX-1 and IL-10, exhibiting protective activity in the mouse gut. Malvidin thus prevented gastric and duodenal ulcers due to prominent anti-inflammatory and antioxidative effects on the gastrointestinal tract that were related to gene expression modulation and an increase in endogenous defense mechanisms.
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页数:17
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共 61 条
[1]  
Aebi H., 1984, METHOD ENZYMOL, V105, P121
[2]   Cochlospermum regium (Mart. ex Schrank) Pilg.: Evaluation of chemical profile, gastroprotective activity and mechanism of action of hydroethanolic extract of its xylopodium in acute and chronic experimental models [J].
Arunachalam, Karuppusamy ;
Damazo, Amilcar Sabino ;
Pavan, Eduarda ;
Oliveira, Darley Maria ;
Figueiredo, Fabiana de Freitas ;
Marra Machado, Marco Tulio ;
Balogun, Sikiru Olaitan ;
Soares, Ilsamar Mendes ;
Barbosa, Robson dos Santos ;
Alvim, Tarso da Costa ;
Ascencio, Sergio Donizeti ;
de Oliveira Martins, Domingos Tabajara .
JOURNAL OF ETHNOPHARMACOLOGY, 2019, 233 :101-114
[3]   Gastrointestinal-Sparing Effects of Novel NSAIDs in Rats with Compromised Mucosal Defence [J].
Blackler, Rory ;
Syer, Stephanie ;
Bolla, Manlio ;
Ongini, Ennio ;
Wallace, John L. .
PLOS ONE, 2012, 7 (04)
[4]   Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia-reperfusion into gastric ulcers [J].
Brzozowski, T ;
Konturek, PC ;
Konturek, SJ ;
Drozdowicz, D ;
Kwiecien, S ;
Pajdo, R ;
Bielanski, W ;
Hahn, EG .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 398 (01) :147-158
[5]   High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women [J].
Cassidy, Aedin ;
Mukamal, Kenneth J. ;
Liu, Lydia ;
Franz, Mary ;
Eliassen, A. Heather ;
Rimm, Eric B. .
CIRCULATION, 2013, 127 (02) :188-196
[6]   Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa [J].
Cheng, Yu-Ting ;
Lu, Chi-Cheng ;
Yen, Gow-Chin .
MOLECULAR NUTRITION & FOOD RESEARCH, 2017, 61 (06)
[7]   Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study [J].
Cheung, Ka Shing ;
Chan, Esther W. ;
Wong, Angel Y. S. ;
Chen, Lijia ;
Wong, Ian C. K. ;
Leung, Wai Keung .
GUT, 2018, 67 (01) :28-35
[8]   Effect of allantoin on experimentally induced gastric ulcers: Pathways of gastroprotection [J].
da Silva, Dayane Moreira ;
Rodrigues Martins, Jose Luis ;
de Oliveira, Danillo Ramos ;
Florentino, Iziara Ferreira ;
Bueno da Silva, Daiany Priscilla ;
Alcantara dos Santos, Fernanda Cristina ;
Costa, Elson Alves .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 821 :68-78
[9]   Hesperidin, a citrus flavanone glycoside, accelerates the gastric healing process of acetic acid-induced ulcer in rats [J].
da Silva, Luisa Mota ;
Pezzini, Bruno Cesar ;
Somensi, Lincon Bordignon ;
Bolda Mariano, Luisa Nathalia ;
Mariott, Mariha ;
Boeing, Thaise ;
dos Santos, Ana Carolina ;
Longo, Bruna ;
Cechinel-Filho, Valdir ;
de Souza, Priscila ;
de Andrade, Sergio Faloni .
CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 308 :45-50
[10]   Gastroduodenal mucosal defense [J].
deFoneska, Arushi ;
Kaunitz, Jonathan D. .
CURRENT OPINION IN GASTROENTEROLOGY, 2010, 26 (06) :604-610