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Cis (1S,3R)-1-(9-adenyl)-3-hydroxycyclopentane inhibits the respiratory burst from polymorphonuclear leukocytes and has in vivo efficacy in an acute and chronic model of inflammation
被引：3
|作者：
Borcherding, DR
Butler, BT
Linnik, MD
Mehdi, S
Dudley, MW
Edwards, CK
机构：
[1] Marion Merrell Dow Res. Institute, Cincinnati, OH 45215-6300
来源：
关键词：
D O I：
10.1080/07328319608002028
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
The adenine-containing carbocyclic nucleosides (1) under bar and (2) under bar were synthesized in optically active form and have been shown to effectively inhibit interferon-gamma priming of Lewis (LEW/N) rat air pouch-derived PMNs. Compound (2) under bar was also shown to have in vivo activity in a LEW/N rat antigen-induced arthritis model which assesses acute and chronic inflammation.
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页码：967 / 979
页数：13
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