Diclofenac-loaded Eudragit S100 nanosuspension for ophthalmic delivery

被引:26
作者
Ahuja, Munish [3 ]
Dhake, Avinash S. [2 ]
Sharma, Surendera K. [3 ]
Majumdar, Dipak K. [1 ]
机构
[1] Univ Delhi, Dept Pharmaceut, Delhi Inst Pharmaceut Sci & Res, New Delhi 110017, India
[2] SMBT Coll Pharm, Tal Igatpuri 422403, Maharashtra, India
[3] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Hisar 125001, Haryana, India
关键词
Anti-inflammatory; diclofenac; Eudragit S100; nanosuspension; ocular; IN-VITRO EVALUATION; EYE; NANOPARTICLES; NANOCAPSULES; KETOROLAC; THERAPY; RELEASE; SYSTEMS;
D O I
10.3109/02652048.2010.523794
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
In this study, diclofenac-loaded Eudragit S100-based nanosuspension was prepared by nanoprecipitation method and characterised for particle size, morphology, in vitro release, and for its in vivo ocular anti-inflammatory activity. The diclofenac-loaded Eudragit S100 nanosuspension was found to have a particle size of 172 nm, polydispersibility index of 0.14 and zeta potential of -23.7 +/- 6.07 mV, indicating that the nanosuspension is fairly stable. The nanosuspended particles were found to be spherical in shape. The nanosuspension was found to provide a sustained in vitro release, following the Higuchi square-root release kinetics. The results indicated that the nanosuspension released the drug by combination of dissolution and diffusion. The in vivo evaluation of nanosuspension in PGE(2)-induced ocular inflammation in rabbit model revealed a significantly (p < 0.05) higher inhibition of PGE(2)-induced polymorphonuclear leukocytes migration and lid-closure scores as compared with the aqueous solution of diclofenac.</.
引用
收藏
页码:37 / 45
页数:9
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