Small-molecule binding at the Src SH2 domain

被引:0
|
作者
Edwards, P [1 ]
机构
[1] Pfizer Global Res & Dev, Lead Discovery Technol, Sandwich, Kent, England
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:54 / 55
页数:2
相关论文
共 50 条
  • [21] Nitrotyrosine peptides activate the src family tyrosine kinase lyn by binding to the SH2 domain
    Mallozzi, C
    Di Stasi, AMM
    Minetti, M
    FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 : S69 - S70
  • [22] Synthesis and evaluation of phosphopeptides containing iminodiacetate groups as binding ligands of the Src SH2 domain
    Ye, Guofeng
    Schuler, Aaron D.
    Ahmadibeni, Yousef
    Morgan, Joel R.
    Faruqui, Absar
    Huang, Kezhen
    Sun, Gongqin
    Zebala, John A.
    Parang, Keykavous
    BIOORGANIC CHEMISTRY, 2009, 37 (04) : 133 - 142
  • [23] Covalent binding of catechols to Src family SH2 domains
    Jagoe, CT
    Kreifels, SE
    Li, JM
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (02) : 113 - 116
  • [24] Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule microarray
    Fu, Jiaqi
    Na, Zhenkun
    Uttamchandani, Mahesh
    Yao, Shao Q.
    CHEMICAL COMMUNICATIONS, 2013, 49 (83) : 9660 - 9662
  • [25] Inhibitors of the Src SH2 domain and Src tyrosine kinase as potential anticancer drugs
    Tranter, D
    DRUG DISCOVERY TODAY, 2001, 6 (04) : 215 - 216
  • [26] Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain
    Nachman, Joseph
    Gish, Gerry
    Virag, Cristina
    Pawson, Tony
    Pomes, Regis
    Pai, Emil
    PLOS ONE, 2010, 5 (06):
  • [27] Ligand specificity switching in the c-Src SH2 domain
    Showalter, SA
    Young, JK
    Nicholson, LK
    BIOPHYSICAL JOURNAL, 1999, 76 (01) : A246 - A246
  • [28] Hierarchy of simulation models in predicting structure and energetics of the Src SH2 domain binding to tyrosyl phosphopeptides
    Verkhivker, GM
    Bouzida, D
    Gehlhaar, DK
    Rejto, PA
    Schaffer, L
    Arthurs, S
    Colson, AB
    Freer, ST
    Larson, V
    Luty, BA
    Marrone, T
    Rose, PW
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (01) : 72 - 89
  • [29] Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design
    Taylor, Jonathan D.
    Ababou, Abdessamad
    Fawaz, Radwan R.
    Hobbs, Christopher J.
    Williams, Mark A.
    Ladbury, John E.
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2008, 73 (04) : 929 - 940
  • [30] Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity
    Jin, Lily L.
    Wybenga-Groot, Leanne E.
    Tong, Jiefei
    Taylor, Paul
    Minden, Mark D.
    Trudel, Suzanne
    McGlade, C. Jane
    Moran, Michael F.
    MOLECULAR & CELLULAR PROTEOMICS, 2015, 14 (03) : 695 - 706