Structure and Absolute Configuration of Aspergilumamide A, a Novel Lumazine Peptide from the Mangrove-Derived Fungus Aspergillus sp.

被引：17

作者：

Zheng, Cai-Juan ^{[1
]}

Wu, Lu-Yong ^{[1
]}

Li, Xiao-Bao ^{[1
]}

Song, Xin-Ming ^{[1
]}

Niu, Zhi-Gang ^{[1
]}

Song, Xiao-Ping ^{[1
]}

Chen, Guang-Ying ^{[1
]}

Wang, Chang-Yun ^{[2
]}

机构：

[1] Hainan Normal Univ, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Peoples R China

[2] Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2015年 / 98卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Aspergillus; Lumazine peptide; Marfey's method; Cytotoxic activity; Antibacterial activity; DERIVATIVES;

D O I：

10.1002/hlca.201400197

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel lumazine peptide, aspergilumamide A (1), as well as a known analog penilumamide (2), were isolated from the mycelia of a marine-derived fungus Aspergillus sp. (33241), obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. The structure of 1 was identified by comprehensive spectroscopic analysis, including 1D- and 2D-NMR, ESI-MS, and MS/MS experiments. The absolute configuration of 1 was determined by Marfey's method.

引用

页码：368 / 373

页数：6

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