Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy

Ti3C2 MXene is a new two-dimensional material exhibiting a variety of novel properties including good photothermal effect, and the capability of Ti3C2 for multimodal tumor therapy is in urgent need of development. Herein, ultrathin Ti3C2 MXene nanosheets (similar to 100 nm) have been synthesized by supplying additive Al3+ to avoid Al loss and employed as a photothermal/photodynamic agent for cancer therapy. The as-obtained nanosheets exhibit outstanding mass extinction coefficient (28.6 Lg(-1) cm(-1) at 808 nm), superior photothermal conversion efficiency (similar to 58.3%), and effective singlet oxygen generation (O-1(2)) upon 808 nm laser irradiation. Based on these Ti3C2 nanosheets, a multifunctional nanoplatform (Ti3C2-DOX) is established via layer-by layer surface modification with doxorubicin (DOX) and hyaluronic acid (HA). In vitro and in vivo experiments disclose that Ti3C2-DOX shows enhanced biocompatibility, tumor specific accumulation, and stimuli-responsive drug release behavior and achieve effective cancer cell killing and tumor tissue destruction through photothermal/photodynamic/chemo synergistic therapy.