Dramatic Impact of ppb Levels of Palladium on the "Copper-Catalyzed" Sonogashira Coupling

被引：75

作者：

Gonda, Zsombor ^{[1
]}

Tolnai, Gergely L. ^{[1
]}

Novak, Zoltan ^{[1
]}

机构：

[1] Eotvos Lorand Univ, Inst Chem, H-1117 Budapest, Hungary

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 39期

关键词：

alkynes; copper; cross-coupling; palladium; synthetic methods; ARYL CHLORIDES; SUZUKI-MIYAURA; TERMINAL ALKYNES; LIGAND-FREE; EFFICIENT; IODIDES; COMPLEXES; GOLD(III); BROMIDES; HALIDES;

D O I：

10.1002/chem.201001880

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladacadabra! The effect of ppb levels of palladium on the "copper-catalyzed" Sonogashira coupling is reported. The observed high sensitivity to palladium impurities queries the existence of pure copper catalysis in the coupling of aryl iodides and terminal acetylenes (see figure). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11822 / 11826

页数：5

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