Electroencephalographic patterns during sleep in children with chromosome 15q11.2-13.1 duplications (Dup15q)

被引：12

作者：

Arkilo, Dimitrios ^{[1
]}

Devinsky, Orrin ^{[2
]}

Mudigoudar, Basanagoud ^{[3
,4
]}

Boronat, Susana ^{[5
]}

Jennesson, Melanie ^{[6
]}

Sassower, Kenneth ^{[7
]}

Vaou, Okeanis Eleni ^{[8
]}

Lerner, Jason T. ^{[9
]}

Jeste, Shafali Spurling ^{[10
]}

Luchsinger, Kadi ^{[11
]}

Thibert, Ronald ^{[7
]}

机构：

[1] PA Childrens Hosp & Clin Minnesota, Minnesota Epilepsy Grp, 225 Smith Ave N,St 201, St Paul, MN 55102 USA

[2] NYU, Dept Neurol, NYU Langone Med Ctr, 240 East 38th St,20th Floor, New York, NY 10016 USA

[3] Le Bonheur Childrens Hosp, Comprehens Epilepsy Program, 848 Adams Ave, Memphis, TN 38103 USA

[4] Le Bonheur Childrens Hosp, Neurosci Ctr, 848 Adams Ave, Memphis, TN 38103 USA

[5] Univ Autonoma Barcelona, Vall dHebron Hosp, Dept Pediat Neurol, P Vall dHebron 119-129, Barcelona 08035, Spain

[6] CHU Reims, Amer Mem Hosp, Dept Pediat Neurol, 47 Rue Cognacq Jay, F-51100 Reims, France

[7] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, 15 Parkman St,835, Boston, MA 02114 USA

[8] Noran Neurol Clin, 2828 Chicago Ave S,200, Minneapolis, MN 55407 USA

[9] Univ Calif Los Angeles, Mattel Childrens Hosp, Dept Pediat, 757 Westwood Plaza, Los Angeles, CA 90095 USA

[10] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Dept Neurol, 710 Westwood Plaza, Los Angeles, CA 90095 USA

[11] Dup15Q Alliance, Fayetteville, NY 13066 USA

来源：

EPILEPSY & BEHAVIOR | 2016年 / 57卷

关键词：

EEG patterns; Sleep; Dup15q syndrome; Children; DEVELOPMENTAL DISORDER; SEIZURES; EPILEPSY;

D O I：

10.1016/j.yebeh.2016.02.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Our objective was to define the EEG features during sleep of children with neurodevelopmental disorders due to copy number gains of 15q11-q13 (Dupl 5q). We retrospectively reviewed continuous EEG recordings of 42 children with Dupl5q (mean age: eight years, 32 with idicl5), and data collected included background activity, interictal epileptiform discharges, sleep organization, and ictal activity. Three patterns were recognized: Pattern 1: Alpha-delta sleep was noted in 14 children (33%), not associated with any clinical changes. Pattern 2: Electrical status epilepticus in sleep was noted in 15 children (35%), all diagnosed with treatment resistant epilepsy. Thirteen of the 15 children had clinical seizures. Pattern 3: Frequent bursts of high amplitude bifrontal predominant, paroxysmal fast activity (12-15 Hz) during non-REM sleep was noted in 15 children (35%). All 15 children had treatment-resistant epilepsy. This is the first report of electroencephalographic patterns during sleep of children with Dup15q reporting alpha delta rhythms, CSWS, and high amplitude fast frequencies. Alpha-delta rhythms are described in children with dysautonomia and/or mood disorders and CSWS in children with developmental regression. The significance of these findings in cognitive function and epilepsy for the children in our cohort needs to be determined with follow-up studies. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：133 / 136

页数：4

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