Plant Pathogenesis-Related Proteins PR-10 and PR-14 as Components of Innate Immunity System and Ubiquitous Allergens

被引：59

作者：

Finkina, Ekaterina I. ^{[1
]}

Melnikova, Dania N. ^{[1
]}

Bogdanov, Ivan V. ^{[1
]}

Ovchinnikova, Tatiana V. ^{[1
]}

机构：

[1] Russian Acad Sci, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Miklukho Maklaya Str 16-10, Moscow 117997, Russia

来源：

CURRENT MEDICINAL CHEMISTRY | 2017年 / 24卷 / 17期

基金：

俄罗斯科学基金会;

关键词：

Innate immunity system; pathogenesis-related proteins; plant defense; Bet v 1 homologs; lipid transfer proteins; ligand binding; allergens; cross reactivity; LIPID-TRANSFER PROTEIN; BIRCH POLLEN ALLERGEN; BET V 1; MAJOR PEACH ALLERGEN; T-CELL RESPONSE; CRYSTAL-STRUCTURE; RESISTANCE RESPONSE; CROSS-REACTIVITY; APPLE ALLERGEN; FOOD ALLERGY;

D O I：

10.2174/0929867323666161026154111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pathogenesis-related (PR) proteins are components of innate immunity system in plants. They play an important role in plant defense against pathogens. Lipid transfer proteins (LTPs) and Bet v 1 homologs comprise of two separate families of PR-proteins. Both LTPs (PR-14) and Bet v 1 homologs (PR-10) are multifunctional small proteins involving in plant response to abiotic and biotic stress conditions. The representatives of these PR-protein families do not show any sequence similarity but have other common biochemical features such as low molecular masses, the presence of hydrophobic cavities, ligand binding properties, and antimicrobial activities. Besides, many members of PR-10 and PR-14 families are ubiquitous plant panallergens which are able to cause sensitization of human immune system and crossreactive allergic reactions to plant food and pollen. This review is aimed at comparative analysis of structure-functional and allergenic properties of the PR-10 and PR-14 families, as well as prospects for their medicinal application.

引用

页码：1772 / 1787

页数：16

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