Caspofungin Etest Susceptibility Testing of Candida Species: Risk of Misclassification of Susceptible Isolates of C. glabrata and C-krusei when Adopting the Revised CLSI Caspofungin Breakpoints

被引：56

作者：

Arendrup, Maiken Cavling ^{[1
]}

Pfaller, Michael A. ^{[2
,3
]}

机构：

[1] Statens Serum Inst, Unit Mycol, Dept Microbiol Surveillance & Res, DK-2300 Copenhagen, Denmark

[2] JMI Labs, Iowa City, IA USA

[3] Univ Iowa, Iowa City, IA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 07期

关键词：

INVASIVE CANDIDIASIS; ALBICANS; MICAFUNGIN; ANIDULAFUNGIN; ECHINOCANDINS;

D O I：

10.1128/AAC.00355-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The purpose of this study was to evaluate the performance of caspofungin Etest and the recently revised CLSI breakpoints. A total of 497 blood isolates, of which 496 were wild-type isolates, were included. A total of 65/496 susceptible isolates (13.1%) were misclassified as intermediate (I) or resistant (R). Such misclassifications were most commonly observed for Candida krusei (73.1%) and Candida glabrata (33.1%). The revised breakpoints cannot be safely adopted for these two species.

引用

页码：3965 / 3968

页数：4