Molecular Testing in Colorectal Cancer Diagnosis of Lynch Syndrome and Personalized Cancer Medicine

被引:27
作者
Shi, Chanjuan [1 ]
Washington, Kay [1 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Med Ctr N C3321, Nashville, TN 37232 USA
关键词
Colorectal cancer; Microsatellite instability; Gene mutations; Personalized cancer medicine; GROWTH-FACTOR RECEPTOR; DNA MISMATCH REPAIR; CETUXIMAB PLUS IRINOTECAN; BRAF V600E MUTATION; K-RAS MUTATIONS; II COLON-CANCER; MICROSATELLITE-INSTABILITY; ADJUVANT CHEMOTHERAPY; STAGE-II; PIK3CA MUTATIONS;
D O I
10.1309/AJCPI83DINULUJNI
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Currently, molecular testing in colorectal cancer (CRC) is aimed at detecting Lynch syndrome and predicting response to anti epidermal growth factor receptor (EGFR) therapies. However, CRC is a complex disease, with at least 3 molecular pathways of carcinogenesis. The importance of the EGFR signaling pathway in colorectal carcinogenesis is underscored by the availability of anti-EGFR monoclonal antibodies for the treatment of some metastatic CRCs. Potentially, mutations in any of the genes in the EGFR signaling pathway may be associated with prognosis and may predict response to anti-EGFR or other targeted therapies. Although not currently the standard of care, molecular testing of CRCs is expanding to include mutational analysis of the genes in the EGFR pathway, in addition to more widely performed tests for identifying cancers with high microsatellite instability. Multiplex molecular prognostic panels for therapeutic decision making in stage II CRCs also represent expanding use of molecular testing for this common cancer.
引用
收藏
页码:847 / 859
页数:13
相关论文
共 118 条
[1]   Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population [J].
Abubaker, J. ;
Bavi, P. ;
Al-Harbi, S. ;
Ibrahim, M. ;
Siraj, A. K. ;
Al-Sanea, N. ;
Abduljabbar, A. ;
Ashari, L. H. ;
Alhomoud, S. ;
Al-Dayel, F. ;
Uddin, S. ;
Al-Kuraya, K. S. .
ONCOGENE, 2008, 27 (25) :3539-3545
[2]  
Aebi S, 1997, CLIN CANCER RES, V3, P1763
[3]  
Aebi S, 1996, CANCER RES, V56, P3087
[4]   The American College of Gastroenterology Emily Couric Lecture-The Adenoma-Carcinoma Sequence Revisited: Has the Era of Genetic Tailoring Finally Arrived [J].
Ahnen, Dennis J. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (02) :190-198
[5]   Histopathological identification of colon cancer with microsatellite instability [J].
Alexander, J ;
Watanabe, T ;
Wu, TT ;
Rashid, A ;
Li, SA ;
Hamilton, SR .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (02) :527-535
[6]   Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer [J].
Amado, Rafael G. ;
Wolf, Michael ;
Peeters, Marc ;
Van Cutsem, Eric ;
Siena, Salvatore ;
Freeman, Daniel J. ;
Juan, Todd ;
Sikorski, Robert ;
Suggs, Sid ;
Radinsky, Robert ;
Patterson, Scott D. ;
Chang, David D. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) :1626-1634
[7]   Kirsten ras mutations in patients with colorectal cancer:: the 'RASCAL II' study [J].
Andreyev, HJN ;
Norman, AR ;
Cunningham, D ;
Oates, J ;
Dix, BR ;
Iacopetta, BJ ;
Young, J ;
Walsh, T ;
Ward, R ;
Hawkins, N ;
Beranek, M ;
Jandik, P ;
Benamouzig, R ;
Jullian, E ;
Laurent-Puig, P ;
Olschwang, S ;
Muller, O ;
Hoffmann, I ;
Rabes, HM ;
Zietz, C ;
Troungos, C ;
Valavanis, C ;
Yuen, ST ;
Ho, JWC ;
Croke, CT ;
O'Donoghue, DP ;
Giaretti, W ;
Rapallo, A ;
Russo, A ;
Bazan, V ;
Tanaka, M ;
Omura, K ;
Azuma, T ;
Ohkusa, T ;
Fujimori, T ;
Ono, Y ;
Pauly, M ;
Faber, C ;
Glaesener, R ;
de Goeij, AFPM ;
Arends, JW ;
Andersen, SN ;
Lövig, T ;
Breivik, J ;
Gaudernack, G ;
Clausen, OPF ;
De Angelis, P ;
Meling, GI ;
Rognum, TO ;
Smith, R .
BRITISH JOURNAL OF CANCER, 2001, 85 (05) :692-696
[8]   A prospective, multicenter, population-based study of BRAF mutational analysis for lynch syndrome screening [J].
不详 .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2008, 6 (02) :206-214
[9]  
[Anonymous], MUTAT RES
[10]   Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review [J].
Baas, Jara M. ;
Krens, Lisanne L. ;
Guchelaar, Henk-Jan ;
Morreau, Hans ;
Gelderblom, Hans .
ONCOLOGIST, 2011, 16 (09) :1239-1249