The Genetics of Colorectal Cancer

被引：16

作者：

Jasperson, Kory ^{[1
]}

Burt, Randall W. ^{[2
]}

机构：

[1] Univ Utah, Huntsman Canc Inst, Dept Internal Med, Salt Lake City, UT 84112 USA

[2] Univ Utah, Huntsman Canc Inst, Dept Internal Med, Salt Lake City, UT 84112 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 24卷 / 04期

关键词：

Hereditary colon cancer; Lynch syndrome; Familial adenomatous polyposis; MUTYH-associated polyposis; Peutz-Jeghers syndrome; Juvenile polyposis; FAMILIAL ADENOMATOUS POLYPOSIS; POPULATION-BASED SERIES; PEUTZ-JEGHERS-SYNDROME; LYNCH-SYNDROME; ENDOMETRIAL CANCER; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; GERMLINE MUTATIONS; DESMOID TUMORS; CLINICAL MANAGEMENT;

D O I：

10.1016/j.soc.2015.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The hereditary colorectal cancer syndromes comprise a heterogeneous group of conditions with varying cancer risks, gastrointestinal polyp types, nonmalignant findings, and inheritance patterns. Although each one is unique in its own right, these syndromes often have overlapping features, making diagnoses difficult in select cases. Obtaining accurate polyp history (histologic type, number, location, and age of onset), cancer history (location, type, and age of onset), and other nonmalignant features is imperative in determining the likely disease diagnosis and thereby the appropriate genetic tests for precise diagnosis in a timely fashion. This process often necessitates collaboration among surgical oncology team members and genetic counselors.

引用

页码：683 / +

页数：22

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