Gender difference in the miotic potency of soman vapor in rats

被引：17

作者：

Dabisch, Paul A. ^{[1
]}

Horsmon, Michael S.

Taylor, James T. ^{[2
]}

Muse, William T.

Miller, Dennis B.

Sommerville, Douglas R.

Mioduszewski, Robert J.

Thomson, Sandra

机构：

[1] USA, Operat Toxicol Team, Edgewood Chem Biol Ctr, AMSRD ECB RT TT, Aberdeen Proving Ground, MD 21010 USA

[2] CNR, Washington, DC 20418 USA

来源：

CUTANEOUS AND OCULAR TOXICOLOGY | 2008年 / 27卷 / 02期

关键词：

acetylcholinesterase; butyrylcholinesterase; gender differences; miosis; nerve agent; pupil constriction; potency comparison; soman;

D O I：

10.1080/15569520802064376

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The present study was undertaken to investigate the miotic potency of soman vapor in the rat, as well as gender differences in the miotic response to soman vapor that have been reported previously for other nerve agents. The results of the present study demonstrate that the miotic potency of soman vapor is significantly less than that of other nerve agents, and that female rats are 2.5-3.0 times more sensitive to soman vapor than male rats. The results also demonstrate that ocular acetylcholinesterase and butyrylcholinesterase activities differ between males and females, although this difference is not likely large enough to account for the observed gender difference.

引用

页码：123 / 133

页数：11

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