Secretin family (Class B) G protein-coupled receptors - from molecular to clinical perspectives

被引：15

作者：

Poyner, David R. ^{[2
]}

Hay, Debbie L. ^{[1
]}

机构：

[1] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand

[2] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 166卷 / 01期

关键词：

G protein-coupled receptor; GPCR; family B; secretin; CGRP; CRYSTAL-STRUCTURE; EXTRACELLULAR DOMAIN; PARATHYROID-HORMONE; CGRP RECEPTOR; NMR STRUCTURE; IDENTIFICATION; PHARMACOLOGY; RECOGNITION; ACTIVATION; MECHANISMS;

D O I：

10.1111/j.1476-5381.2011.01810.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Family B G protein-coupled receptors represent an important but under-researched group of receptors. This edition of the British Journal of Pharmacology considers the roles and pharmacology of a number of these receptors. Whilst common themes emerge, it is clear that more work is needed to understand the details of each receptor in order to properly exploit them therapeutically.

引用

页码：1 / 3

页数：3

共 31 条

[21] Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding [J].

Kusano, Seisuke ;

Kukimoto-Niino, Mutsuko ;

Hino, Nobumasa ;

Ohsawa, Noboru ;

Okuda, Ken-ichi ;

Sakamoto, Kensaku ;

Shirouzu, Mikako ;

Shindo, Takayuki ;

Yokoyama, Shigeyuki .

PROTEIN SCIENCE, 2012, 21 (02) :199-210

[22] The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling [J].

Kuwasako, Kenji ;

Hay, Debbie L. ;

Nagata, Sayaka ;

Hikosaka, Tomomi ;

Kitamura, Kazuo ;

Kato, Johji .

BRITISH JOURNAL OF PHARMACOLOGY, 2012, 166 (01) :137-150

[23] Conformational switches in the VPAC1 receptor [J].

Langer, Ingrid .

BRITISH JOURNAL OF PHARMACOLOGY, 2012, 166 (01) :79-84

[24] Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor [J].

Miller, Laurence J. ;

Dong, Maoqing ;

Harikumar, Kaleeckal G. .

BRITISH JOURNAL OF PHARMACOLOGY, 2012, 166 (01) :18-26

[25] Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine [J].

Moore, Eric L. ;

Salvatore, Christopher A. .

BRITISH JOURNAL OF PHARMACOLOGY, 2012, 166 (01) :66-78

[26] Structural Basis for Hormone Recognition by the Human CRFR2α G Protein-coupled Receptor [J].

Pal, Kuntal ;

Swaminathan, Kunchithapadam ;

Xu, H. Eric ;

Pioszak, Augen A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (51) :40351-40361

[27] Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor [J].

Parthier, Christoph ;

Kleinschmidt, Martin ;

Neumann, Piotr ;

Rudolph, Rainer ;

Manhart, Susanne ;

Schlenzig, Dagmar ;

Fanghaenel, Joerg ;

Rahfeld, Jens-Ulrich ;

Demuth, Hans-Ulrich ;

Stubbs, Milton T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (35) :13942-13947

[28] Molecular recognition of parathyroid hormone by its G protein-coupled receptor [J].

Pioszak, Augen A. ;

Xu, H. Eric .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (13) :5034-5039

[29] GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities [J].

Roth, Jonathan D. ;

Erickson, Mary R. ;

Chen, Steve ;

Parkes, David G. .

BRITISH JOURNAL OF PHARMACOLOGY, 2012, 166 (01) :121-136

[30] Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain [J].

Runge, Steffen ;

Thogersen, Henning ;

Madsen, Kjeld ;

Lau, Jesper ;

Rudolph, Rainer .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (17) :11340-11347

← 1 2 3 4 →