Rats: gnawing through the barriers to understanding genetic susceptibility and breast cancer

被引：1

作者：

Blackburn, Anneke C. ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

来源：

BREAST CANCER RESEARCH | 2011年 / 13卷 / 05期

关键词：

MCS5A; LOCUS;

D O I：

10.1186/bcr2939

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advances in genotyping technology have provided us with a large number of genetic loci associated with cancer susceptibility; however, our ability to understand the functional effects of the genetic variants of these loci remains limited. In the previous issue, Smits and colleagues demonstrate the use of congenic rat strains to discover that the Mcs5a breast cancer susceptibility locus is most likely acting through the immune system, via novel transcriptional regulatory mechanisms. This challenges our conventional thinking of cancer susceptibility and gene regulation pathways, and illustrates the potential for rodent models to help us functionally characterize polymorphisms of cancer-associated loci.

引用

页数：3

共 8 条

[1] Map Making in the 21st Century: Charting Breast Cancer Susceptibility Pathways in Rodent Models [J].

Blackburn, Anneke C. ;

Jerry, D. Joseph .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2011, 16 (01) :57-64

[2] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[3]

Lan H, 2001, GENETICS, V157, P331

[4] Common Genetic Variation in Candidate Genes and Susceptibility to Subtypes of Breast Cancer [J].

Mavaddat, Nasim ;

Dunning, Alison M. ;

Ponder, Bruce A. J. ;

Easton, Douglas F. ;

Pharoah, Paul D. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (01) :255-259

[5] Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk [J].

Samuelson, David J. ;

Hesselson, Stephanie E. ;

Aperavich, Beth A. ;

Zan, Yunhong ;

Haag, Jill D. ;

Trentham-Dietz, Amy ;

Hampton, John M. ;

Mau, Bob ;

Chen, Kai-Shun ;

Baynes, Caroline ;

Khaw, Kay-Tee ;

Luben, Robert ;

Perkins, Barbara ;

Shah, Mitul ;

Pharoah, Paul D. ;

Dunning, Alison M. ;

Easton, Doug F. ;

Ponder, Bruce A. ;

Gould, Michael N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (15) :6299-6304

[6] The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions [J].

Smits, Bart M. G. ;

Sharma, Deepak ;

Samuelson, David J. ;

Woditschka, Stephan ;

Mau, Bob ;

Haag, Jill D. ;

Gould, Michael N. .

BREAST CANCER RESEARCH, 2011, 13 (04)

[7]

SMITS BMG, 2011, NUCL ACIDS RES 0913

[8] Immune-mediated dormancy: an equilibrium with cancer [J].

Teng, Michele W. L. ;

Swann, Jeremy B. ;

Koebel, Catherine M. ;

Schreiber, Robert D. ;

Smyth, Mark J. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (04) :988-993

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