Systematic strontium substitution in hydroxyapatite coatings on titanium via micro-arc treatment and their osteoblast/osteoclast responses

被引：152
作者：
Chung, Chi-Jen [1 ]
Long, Han-Yun [2 ]
机构：
[1] Cent Taiwan Univ Sci & Technol, Dept Dent Technol & Mat Sci, Taichung 40601, Taiwan
[2] Feng Chia Univ, Dept Mat Sci & Engn, Taichung 40724, Taiwan
来源：
ACTA BIOMATERIALIA | 2011年 / 7卷 / 11期
关键词：
Micro-arc treatment; Strontium-containing hydroxyapatite; Osteoblast; Osteoclast; Osseointegration; BONE-FORMATION; SR; OSTEOBLAST; DEPOSITION; OXIDATION; CEMENT;
D O I：
10.1016/j.actbio.2011.07.004
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
This study attempts to enhance the osseointegration of titanium implants by adopting a micro-arc treatment (MAT) capable of replacing calcium (Ca) with different percentages of strontium (Sr) in order to fabricate strontium-containing hydroxyapatite (Sr-HAp) coatings. Sr, regarded as a significant therapy promoting bone mass and bone strength, has a dual mechanism, enhancing osteoblast differentiation and inhibiting osteoclast differentiation. This study also investigates how Sr content affects the microstructure of and osteoblast/osteoclast growth on the coatings. Experimental results indicate that an increase in the Sr content in the electrolyte bath results in a greater degree of Sr substitution at Ca sites within the HAp phase, facilitating the formation of Sr-HAp coatings with Sr fully solid soluble in the HAP phase. Irrespective of the Sr content, most coatings are similar in porous morphology and pore size. Additionally, the Sr-HAp coating shows higher osteoblast compatibility than raw titanium metal and the HAp coating. Moreover, cell adhesion and proliferation after 48 h was greater than that after 4 h, indicating that Sr can stimulate osteoblast adhesion and proliferation. Further, Sr significantly inhibits osteoclast differentiation when the Sr-HAp coatings exceed 38.9 at.% Sr. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：4081 / 4087
页数：7
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