Evaluation of gastric cancer risk using topography of histological gastritis: A large-scaled cross-sectional study

被引：22

作者：

Imagawa, Shinobu ^{[1
]}

Yoshihara, Masaharu

Ito, Masanori ^{[1
]}

Yoshida, Shigeto ^{[2
]}

Wada, Yoshihiro ^{[1
]}

Tatsugami, Masana ^{[1
]}

Takamura, Akemi ^{[1
]}

Tanaka, Shinji ^{[2
]}

Haruma, Ken ^{[3
]}

Chayama, Kazuaki ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Minami Ku, Hiroshima 7348551, Japan

[2] Hiroshima Univ Hosp, Dept Endoscopy, Higashihiroshima, Japan

[3] Kawasaki Med Sch, Dept Internal Med, Div Gastroenterol, Kurashiki, Okayama, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 07期

关键词：

gastritis; updated Sydney system; pepsinogen; gastric cancer;

D O I：

10.1007/s10620-007-0077-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We evaluated the topography of histological gastritis, which may be risk factors for gastric cancer (GCa). A total of 530 Helicobacter pylori-positive patients underwent diagnostic upper-gastrointestinal endoscopy. Biopsy specimens were obtained from the gastric antrum and body to assess the grade of gastritis. Subjects were divided into four groups by the topography of active gastritis (antrum predominant gastritis, AP; pan-gastritis with or without corpus atrophy, Pan-1 and Pan-2; and corpus predominant gastritis, CP). A higher prevalence of GCa followed the order of Pan 2 -> CP -> Pan 1 -> AP. The age of patients decreased in the same order. When we set Pan 2 and CP as a high-risk group, the sensitivity and specificity for GCa detection were 77.3 and 54.7%, which were superior to the serum criteria using pepsinogens. These suggest that topography of histologic gastritis is an important marker to identify the high-risk group.

引用

页码：1818 / 1823

页数：6

共 24 条

[1]

Aydin O, 2003, WORLD J GASTROENTERO, V9, P2232

[2] Interobserver variation in the histopathological scoring of Helicobacter pylori related gastritis [J].

Chen, XY ;

van der Hulst, RWM ;

Bruno, MJ ;

van der Ende, A ;

Xiao, SD ;

Tytgat, GNJ ;

Ten Kate, FJW .

JOURNAL OF CLINICAL PATHOLOGY, 1999, 52 (08) :612-615

[3] Host factors are important in determining clinical outcomes of Helicobacter pylori infection [J].

Chiba, T ;

Seno, H ;

Marusava, H ;

Wakatsuki, Y ;

Okazaki, K .

JOURNAL OF GASTROENTEROLOGY, 2006, 41 (01) :1-9

[4] Classification and grading of gastritis - The updated Sydney System [J].

Dixon, MF ;

Genta, RM ;

Yardley, JH ;

Correa, P ;

Batts, KP ;

Dahms, BB ;

Filipe, MI ;

Haggitt, RC ;

Haot, J ;

Hui, PK ;

Lechago, J ;

Lewin, K ;

Offerhaus, JA ;

Price, AB ;

Riddell, RH ;

Sipponen, P ;

Solcia, E ;

Watanabe, H .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (10) :1161-1181

[5]

Goto T, 1999, CLIN CANCER RES, V5, P1411

[6] HELICOBACTER-PYLORI INFECTION, SERUM GASTRIN, AND GASTRIC-ACID SECRETION IN TEENAGE SUBJECTS WITH DUODENAL-ULCER, GASTRITIS, OR NORMAL MUCOSA [J].

HARUMA, K ;

KAWAGUCHI, H ;

KOHMOTO, K ;

OKAMOTO, S ;

YOSHIHARA, M ;

SUMII, K ;

KAJIYAMA, G .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1995, 30 (04) :322-326

[7] K-ras mutation in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer [J].

Hiyama, T ;

Haruma, K ;

Kitadai, Y ;

Masuda, H ;

Miyamoto, M ;

Tanaka, S ;

Yoshihara, M ;

Shimamoto, F ;

Chayama, K .

INTERNATIONAL JOURNAL OF CANCER, 2002, 97 (05) :562-566

[8]

Kawaguchi H, 1996, AM J GASTROENTEROL, V91, P959

[9] Magnifying gastroendoscopy for diagnosis of histologic gastritis in the gastric antrum [J].

Kim, S ;

Haruma, K ;

Ito, M ;

Tanaka, S ;

Yoshihara, M ;

Chayama, K .

DIGESTIVE AND LIVER DISEASE, 2004, 36 (04) :286-291

[10] Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk? [J].

Kodama, K ;

Sumii, K ;

Kawano, M ;

Kido, T ;

Nojima, K ;

Sumii, M ;

Haruma, K ;

Yoshihara, M ;

Chayama, K .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2003, 15 (09) :987-993

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