The GH/IGF-1 system in critical illness

被引：67

作者：

Elijah, Itoro E.

Branski, Ludwik K.

Finnerty, Celeste C.

Herndon, David N. ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Surg, Galveston, TX 77550 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2011年 / 25卷 / 05期

基金：

美国国家卫生研究院;

关键词：

trauma; burns; hypermetabolism; protein wasting; IGFBP-3; hepatic acute care response; gut atrophy; nutrition; mortality; anabolic therapy; GROWTH-FACTOR-I; HORMONE TREATMENT; GENE-TRANSFER; BACTERIAL TRANSLOCATION; CATIONIC LIPOSOMES; MESSENGER-RNA; EXPRESSION; THERAPY; PROTEINS; SERUM;

D O I：

10.1016/j.beem.2011.06.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) axis plays a pivotal role in critical illness, with a derangement leading to profound changes in metabolism. Protein wasting with skeletal muscle loss, delayed wound healing, and impaired recovery of organ systems are some of the most feared consequences. The use of human recombinant Growth Hormone (rhGH) and Insulin-like Growth Factor-1 (IGF-1) - alone and in combination - has been studied extensively in preclinical and clinical trials. This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：759 / 767

页数：9

共 74 条

[71] OPTIMIZING LIPOSOME-MEDIATED GENE-TRANSFER IN PRIMARY RAT SEPTOHIPPOCAMPAL CELL-CULTURES [J].