Resolution of (±)-mandelic- and (±)-2-(chlorophenoxy)propionic-acid derivatives by crystallization of their diastereomeric amides with (R)- or (S)-α-arylethylamines

被引：4
作者：
Jourdain, F
Hirokawa, T
Kogane, T
机构：
[1] Kanagawa Ind Technol & Res Inst, Fundamental Technol Div, Kanagawa 2430435, Japan
[2] Yokohama Natl Univ, Ctr Corp Res & Dev, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 12期
关键词：
D O I：
10.1016/S0040-4039(99)00169-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An alternative and cost effective route for the resolution in high ees (95-99%) of (+/-)-mandelic- and (+/-)-2-(chlorophenoxy)propionic- acid derivatives is reported. The key step involves the covalent derivatization and separation of their diastereomeric amides with (R)- or (S)-alpha-arylethylamines. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2307 / 2310
页数：4
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