Plasma and RBCs antioxidant status in occupational male pesticide sprayers

被引：114

作者：

Prakasam, A

Sethupathy, S ^{[1
]}

Lalitha, S

机构：

[1] Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India

[2] Annamalai Univ, Div Biochem, Rajah Muthiah Med Coll & Hosp, Annamalainagar 608002, Tamil Nadu, India

来源：

CLINICA CHIMICA ACTA | 2001年 / 310卷 / 02期

关键词：

sprayers; TBARS; antioxidants and cellular enzymes;

D O I：

10.1016/S0009-8981(01)00487-9

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A total of forty-one (n = 41) male, healthy agricultural sprayers, exposed to pesticides for 5 years, were compared with twenty one (n = 21) controls matched for age and economic status with respect to free radical generation, lipid peroxidation, antioxidant status and concentration of cellular enzymes were determined. Significantly increased TBARS (thiobarbituric acid reactive substances) were observed (P < 0.001) in sprayer populations when compared to controls. The concentration of antioxidants such as glutathione (GSH), alpha -tocopherol, ascorbic acid and ceruloplasmin were significantly altered when compared to controls, and the activities of antioxidant enzymes were remarkably elevated (P < 0.001) in sprayer population's, when compared to controls. <(c)> 2001 Elsevier Science B.V. All rights reserved.

引用

页码：107 / 112

页数：6

共 43 条

[1]

Al-Saleh Iman A., 1994, Journal of Environmental Pathology Toxicology and Oncology, V13, P151

[2] Biomarkers of human exposure to pesticides [J].

Anwar, WA .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1997, 105 :801-806

[3]

BAKER H, 1980, NUTR REP INT, V21, P531

[4] THE ANTIOXIDANT ROLE OF VITAMIN-C [J].

BENDICH, A ;

MACHLIN, LJ ;

SCANDURRA, O ;

BURTON, GW ;

WAYNER, DDM .

ADVANCES IN FREE RADICAL BIOLOGY AND MEDICINE, 1986, 2 (02) :419-444

[5]

BENNET CA, 1967, STAT ANAL CHEM CHEM, P105

[6] EFFECT OF SODIUM NITRITE ON RED CELL GSH [J].

BEUTLER, E ;

KELLY, BM .

EXPERIENTIA, 1963, 19 (02) :96-&

[7]

BEUTLER K, 1984, RED CELL METABOLISM

[8] The influence of antioxidant nutrients on platelet function in healthy volunteers [J].

Calzada, C ;

Bruckdorfer, KR ;

RiceEvans, CA .

ATHEROSCLEROSIS, 1997, 128 (01) :97-105

[9]

Chung TW, 1998, DIABETIC MED, V15, P380, DOI 10.1002/(SICI)1096-9136(199805)15:5<380::AID-DIA592>3.0.CO

[10]

2-8

← 1 2 3 4 5 →