Cancer and Autoimmune Diseases: A Tale of Two Immunological Opposites?

被引：24
作者：
Elkoshi, Zeev [1 ]
机构：
[1] Taro Pharmaceut Ind Ltd, Res & Dev Dept, Haifa, Israel
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
cancer; autoimmune diseases; reactive oxygen species; standardized incidence ratio; hazard ratio; regulatory T cells; inflammation; major histocompability complex; REGULATORY T-CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX; MHC CLASS-I; GROWTH-FACTOR-BETA; CONTROLS PHAGOSOMAL PH; OXIDATIVE STRESS; IFN-GAMMA; TGF-BETA; ANTIGEN-EXPRESSION; DENDRITIC CELLS;
D O I：
10.3389/fimmu.2022.821598
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The present article compares, side-by-side, cancer and autoimmune diseases in terms of innate and adaptive immune cells involvement, MHC Class I and Class II expression, TGF beta effect, immune modulating drugs effect and the effect of reactive oxygen species. The change in the inflammatory immune reaction during the progress of cancer and the effect of this change on the comorbidity of autoimmune diseases and cancer are discussed. The similar inflammatory properties of autoimmune diseases and early cancer, and the contrasting inflammatory properties of autoimmune diseases and advanced cancer elucidate the increased incidence of many types of cancer in patients with pre-existing autoimmune diseases and the decreased cancer-specific mortality of these patients. Stage-dependent effects of reactive oxygen-species on tumor proliferation are an additional probable cause for these epidemiological observations. The relationship: {standardized incidence ratio (SIR)} > {cancer-specific hazard ratio (HR)} for cancer patients with a history of autoimmune diseases is substantiated and rationalized.
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页数：13
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