Palladium-Catalyzed Cascade Hydrosilylation and Amino-Methylation of Isatin Derivatives

被引：11

作者：

Liu, Yue ^{[1
,2
]}

Xia, Yun-Tao ^{[1
,2
]}

Cui, Su-Hang ^{[1
,2
]}

Ji, Yi-Gang ^{[1
,2
,3
]}

Wu, Lei ^{[1
,2
]}

机构：

[1] Nanjing Agr Univ, Coll Sci, Jiangsu Key Lab Pesticide Sci, Nanjing 210095, Peoples R China

[2] Nanjing Agr Univ, Coll Sci, Dept Chem, Nanjing 210095, Peoples R China

[3] Jiangsu Second Normal Univ, Dept Life Sci & Chem, Jiangsu Key Lab Biofunct Mol, Nanjing 210013, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 13期

关键词：

Palladium catalysis; Hydrosilylation; Aminomethylation; Cascade Reaction; Isatin Derivatives; CARBOXYLIC-ACID DERIVATIVES; TERTIARY AMIDES; SECONDARY AMIDES; CHEMOSELECTIVE REDUCTION; SELF-ENCAPSULATION; SILANE-REDUCTION; IRON; HYDROSILANES; CARBOXAMIDES; TRANSITION;

D O I：

10.1002/adsc.202000266

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We demonstrate that using palladium acetate as a catalyst for reduction of DMF and isatin derivatives by hydrosilanes, a cascade hydrosilylation and amino-methylation reaction can be realized. With DMF as a reactant and a solvent, the in-situ generated siloxymethylamine intermediate, an adduct of DMF and hydrosilanes, smoothly participates in the successive stages, providing a serials of Si, N-functionalized indolin-2-ones in moderate to good yields. This strategy exhibits high chemoselectivity toward carbonyl moieties reduction among the substrates.

引用

页码：2632 / 2636

页数：5

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