Tumor immunolocalization using 124I-iodine-labeled JAA-F11 antibody to Thomsen-Friedenreich alpha-linked antigen

被引:22
作者
Chaturvedi, Richa [1 ]
Heimburg, Jamie [2 ]
Yan, Jun [1 ]
Koury, Stephen [1 ]
Sajjad, Munawwar [3 ]
Abdel-Nabi, Hani H. [3 ]
Rittenhouse-Olson, Kate [1 ,2 ]
机构
[1] SUNY Buffalo, Dept Biotech & Clin Lab Sci, Buffalo, NY 14214 USA
[2] SUNY Buffalo, Dept Microbiol & Immunol, Buffalo, NY 14214 USA
[3] SUNY Buffalo, Dept Nucl Med, Buffalo, NY 14214 USA
关键词
immunolocalization; biodistribution; micro-PET; radiolabeled monoclonal antibody; JAA-F11; TF-Ag; breast carcinoma;
D O I
10.1016/j.apradiso.2007.07.029
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Clinical immunolocalization has been attempted by others with an anti-Thomsen-Friedenreich antigen (TF-Ag) mAb that bound both alpha- and beta-linked TF-Ag. In this report, I-124-labeled mAb JAA-F11 specific for alpha-linked TF-Ag showed higher tumor specificity in in vivo micro-positron emission tomography (micro-PET) of the mouse mammary adenocarcinoma line, 4Tl, showing no preferential uptake by the kidney. Labeled product remained localized in the tumor for at least 20 days. Glycan array analysis showed structural specificity of the antibody. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:278 / 287
页数:10
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