ELECTROCHEMICAL DETERMINATION OF ANTI-HYPERLIPIDEMIC DRUG EZETIMIBE BASED ON ITS OXIDATION ON SOLID ELECTRODES

被引：16
|
作者：
Kul, Dilek [2 ]
Uslu, Bengi [1 ]
Ozkan, Sibel A. [1 ]
机构：
[1] Ankara Univ, Dept Analyt Chem, Fac Pharm, TR-06100 Ankara, Turkey
[2] Karadeniz Tech Univ, Fac Pharm, Trabzon, Turkey
来源：
ANALYTICAL LETTERS | 2011年 / 44卷 / 07期
关键词：
Boron-doped diamond electrode; Ezetimibe; Glassy carbon electrode; Pharmaceuticals; Voltammetry; PHARMACEUTICAL FORMULATIONS; ATORVASTATIN CALCIUM; LIQUID-CHROMATOGRAPHY; TABLET FORMULATION; DIFFERENTIAL-PULSE; DOSAGE FORMS; HPTLC METHOD; VALIDATION; SIMVASTATIN; VOLTAMMETRY;
D O I：
10.1080/00032719.2010.512676
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Ezetimibe is the first of a new class of drugs that selectively inhibits cholesterol absorption in the small intestine and reduces plasma LDL cholesterol. In this study, electrochemical oxidation of ezetimibe was investigated on carbon based electrodes and a single and irreversible peak at both electrodes was observed. A linear response was detected between 2 x 10(-6) and 8 x 10(-5) M with glassy carbon electrode and between 2 x 10(-6) and 2 x 10(-4) M with a boron-doped diamond electrode in 0.1 M H2SO4 supporting electrolyte. The proposed methods were successfully applied for the determination of ezetimibe from pharmaceutical dosage forms and human serum samples.
引用
收藏
页码：1341 / 1357
页数：17
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