Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene

被引：17

作者：

Cupit, Pauline M. ^{[1
]}

Steinauer, Michelle L. ^{[2
]}

Tonnessen, Bradley W. ^{[1
]}

Agola, L. Eric ^{[3
]}

Kinuthia, Joseph M. ^{[3
]}

Mwangi, Ibrahim N. ^{[3
]}

Mutuku, Martin W. ^{[3
]}

Mkoji, Gerald M. ^{[3
]}

Loker, Eric S. ^{[1
]}

Cunningham, Charles ^{[1
]}

机构：

[1] Univ New Mexico, Dept Biol, Ctr Evolutionary & Theoret Immunol, Albuquerque, NM 87131 USA

[2] Oregon State Univ, Coll Vet Med, Corvallis, OR 97331 USA

[3] Kenya Govt Med Res Ctr, Ctr Biotechnol Res & Dev, Nairobi, Kenya

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2011年 / 41卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Schistosoma; Polymorphism; Tetraspanin-2; Genotype; Kozak sequence; Vaccine; JAPONICUM; PROTEINS; ORGANIZATION; DOMAINS;

D O I：

10.1016/j.ijpara.2011.07.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya. (C) 2011 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1249 / 1252

页数：4

共 21 条

[1] Molecular characterization of Schistosoma japonicum tegument protein tetraspanin-2:: Sequence variation and possible implications for immune evasion [J].

Cai, Pengfei ;

Bu, Lingyi ;

Wang, Jian ;

Wang, Zhensheng ;

Zhong, Xiang ;

Wang, Heng .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 372 (01) :197-202

[2] Lateral organization of membrane proteins: tetraspanins spin their web [J].

Charrin, Stephanie ;

Le Naour, Francois ;

Silvie, Olivier ;

Milhiet, Pierre-Emmanuel ;

Boucheix, Claude ;

Rubinstein, Eric .

BIOCHEMICAL JOURNAL, 2009, 420 :133-154

[3] The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008 [J].

Fenwick, A. ;

Webster, J. P. ;

Bosque-Oliva, E. ;

Blair, L. ;

Fleming, F. M. ;

Zhang, Y. ;

Garba, A. ;

Stothard, J. R. ;

Gabrielli, A. F. ;

Clements, A. C. A. ;

Kabatereine, N. B. ;

Toure, S. ;

Dembele, R. ;

Nyandindi, U. ;

Mwansa, J. ;

Koukounari, A. .

PARASITOLOGY, 2009, 136 (13) :1719-1730

[4]

GONNERT R, 1977, Z PARASITENKD, V52, P129, DOI 10.1007/BF00389899

[5] Schistosomiasis control:: keep taking the tablets [J].

Hagan, P ;

Appleton, CC ;

Coles, GC ;

Kusel, JR ;

Tchuem-Tchuenté, LA .

TRENDS IN PARASITOLOGY, 2004, 20 (02) :92-97

[6] Developing vaccines to combat hookworm infection and intestinal schistosomiasis [J].

Hotez, Peter J. ;

Bethony, Jeffrey M. ;

Diemert, David J. ;

Pearson, Mark ;

Loukas, Alex .

NATURE REVIEWS MICROBIOLOGY, 2010, 8 (11) :814-826

[7] Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden [J].

Hotez, Peter J. ;

Kamath, Aruna .

PLOS NEGLECTED TROPICAL DISEASES, 2009, 3 (08)

[8] Structural organization and interactions of transmembrane domains in tetraspanin proteins [J].

Kovalenko, OV ;

Metcalf, DG ;

DeGrado, WF ;

Hemler, ME .

BMC STRUCTURAL BIOLOGY, 2005, 5

[9] Wild and domesticated animals as reservoirs of Schistosomiasis mansoni in Brazil [J].

Modena, Celina Maria ;

Lima, Walter dos Santos ;

Zech Coelho, Paulo Marcos .

ACTA TROPICA, 2008, 108 (2-3) :242-244

[10] Origin and diversification of the human parasite Schistosoma mansoni [J].

Morgan, JAT ;

Dejong, RJ ;

Adeoye, GO ;

Ansa, EDO ;

Barbosa, CS ;

Brémond, P ;

Cesari, IM ;

Charbonnel, N ;

Corrêa, LR ;

Coulibaly, G ;

D'Andrea, PS ;

De Souza, CP ;

Doenhoff, MJ ;

File, S ;

Idris, MA ;

Incani, RN ;

Jarne, P ;

Karanja, DMS ;

Kazibwe, F ;

Kpikpi, J ;

Lwambo, NJS ;

Mabaye, A ;

Magalhaes, LA ;

Makundi, A ;

Moné, H ;

Mouahid, G ;

Muchemi, GM ;

Mungai, BN ;

Séne, M ;

Southgate, V ;

Tchuenté, LAT ;

Théron, A ;

Yousif, F ;

Magalhaes, EMZ ;

Mkoji, GM ;

Loker, ES ;

Loker, ES .

MOLECULAR ECOLOGY, 2005, 14 (12) :3889-3902

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