Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis

被引：105
作者：
Inoue, Natsumi [1 ]
Shimizu, Masaki [1 ]
Tsunoda, Shinichiro [2 ]
Kawano, Mitsuhiro [3 ]
Matsumura, Masami [4 ]
Yachie, Akihiro [1 ]
机构：
[1] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Med, Dept Pediat, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan
[2] Coll Med, Dept Internal Med, Div Rheumatol, Nishinomiya, Hyogo, Japan
[3] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Med, Div Rheumatol,Dept Internal Med, Kanazawa, Ishikawa, Japan
[4] Jichi Med Univ Hosp, Div Gen Internal Med, Shimotsuke, Japan
来源：
CLINICAL IMMUNOLOGY | 2016年 / 169卷
基金：
日本学术振兴会;
关键词：
Interleukin-18; Adult-onset Still's disease; Systemic juvenile idiopathic arthritis; Macrophage activation syndrome; MACROPHAGE ACTIVATION SYNDROME; KILLER-CELL DYSFUNCTION; RHEUMATOID-ARTHRITIS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; DIAGNOSTIC-SIGNIFICANCE; SERUM INTERLEUKIN-6; INTERFERON-GAMMA; PATHOGENESIS; MARKER; CLASSIFICATION;
D O I：
10.1016/j.clim.2016.05.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To compare pro-inflammatory cytokine profiles and kinetics inpatients with adult-onset Still's disease (AOSD) to those in patients with systemic juvenile idiopathic arthritis (s-JIA), we analyzed serum cytokine concentrations in 33 patients with AOSD and 77 patients with s-JIA and compared them with clinical features. Patients with AOSD and s-JIA shared a common cytokine profile pattern of a significant increase in IL-18. Patients with AOSD were classified into two subgroups based on serum IL-6 and IL-18 levels. The number of patients with arthritis was significantly higher in the IL-6-dominant subgroup. The cytokine patterns associated with s-JIA and AOSD share common features, such as a significant and predominant increase in IL-18. Distinct IL-6- and IL-18-based cytokine profiles might be responsible for distinct clinical manifestations. The presence of two distinct subgroups in patients with both diseases further supports the view that s-JIA and AOSD share a disease category. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：8 / 13
页数：6
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