Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis

被引：105

作者：

Inoue, Natsumi ^{[1
]}

Shimizu, Masaki ^{[1
]}

Tsunoda, Shinichiro ^{[2
]}

Kawano, Mitsuhiro ^{[3
]}

Matsumura, Masami ^{[4
]}

Yachie, Akihiro ^{[1
]}

机构：

[1] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Med, Dept Pediat, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan

[2] Coll Med, Dept Internal Med, Div Rheumatol, Nishinomiya, Hyogo, Japan

[3] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Med, Div Rheumatol,Dept Internal Med, Kanazawa, Ishikawa, Japan

[4] Jichi Med Univ Hosp, Div Gen Internal Med, Shimotsuke, Japan

来源：

CLINICAL IMMUNOLOGY | 2016年 / 169卷

基金：

日本学术振兴会;

关键词：

Interleukin-18; Adult-onset Still's disease; Systemic juvenile idiopathic arthritis; Macrophage activation syndrome; MACROPHAGE ACTIVATION SYNDROME; KILLER-CELL DYSFUNCTION; RHEUMATOID-ARTHRITIS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; DIAGNOSTIC-SIGNIFICANCE; SERUM INTERLEUKIN-6; INTERFERON-GAMMA; PATHOGENESIS; MARKER; CLASSIFICATION;

D O I：

10.1016/j.clim.2016.05.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To compare pro-inflammatory cytokine profiles and kinetics inpatients with adult-onset Still's disease (AOSD) to those in patients with systemic juvenile idiopathic arthritis (s-JIA), we analyzed serum cytokine concentrations in 33 patients with AOSD and 77 patients with s-JIA and compared them with clinical features. Patients with AOSD and s-JIA shared a common cytokine profile pattern of a significant increase in IL-18. Patients with AOSD were classified into two subgroups based on serum IL-6 and IL-18 levels. The number of patients with arthritis was significantly higher in the IL-6-dominant subgroup. The cytokine patterns associated with s-JIA and AOSD share common features, such as a significant and predominant increase in IL-18. Distinct IL-6- and IL-18-based cytokine profiles might be responsible for distinct clinical manifestations. The presence of two distinct subgroups in patients with both diseases further supports the view that s-JIA and AOSD share a disease category. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：8 / 13

页数：6

共 56 条

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