Tumor Sidedness Is Associated with Survival in Patients with Synchronous Colorectal Peritoneal Carcinomatosis

被引:3
作者
Matsuda, Kenji [1 ]
Tamura, Koichi [1 ]
Iwamoto, Hiromitsu [1 ]
Mizumoto, Yuki [1 ]
Mitani, Yasuyuki [1 ]
Nakamura, Yuki [1 ]
Murakami, Daisuke [1 ]
Sakanaka, Toshihiro [1 ]
Yamaue, Hiroki [1 ]
机构
[1] Wakayama Med Univ, Sch Med, Dept Surg 2, 811-1 Kimiidcra, Wakayama 6408510, Japan
关键词
Tumor sidedness; Colorectal peritoneal carcinomatosis; Macroscopically complete resection; INTRAPERITONEAL CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; HEPATIC RESECTION; CANCER; LOCATION; POPULATION;
D O I
10.1159/000505128
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Synchronous colorectal peritoneal carcinomatosis (SCPC) is not a rare entity, and the prognosis is extremely poor compared to other metastatic sites such as the liver and lung. Therefore, optimal treatment based on tumor characteristics is needed. Recently, the tumor sidedness of colorectal cancer has been reported as one of the prognostic factors and also as a key factor for the treatment strategy. The purpose of this study was to assess the clinical impact of tumor sidedness in patients with SCPC. Methods: A total of 189 cases of SCPC were identified in a retrospective database at Wakayama Medical University Hospital (WMUH) between 1998 and 2014, and were analyzed with a special focus on tumor location. Results: In multivariate analysis, a right-sided location (p = 0.02) and the presence of liver metastases (p < 0.001) were found to be the worst prognostic factors. The median survival time (MST) with right-sided and with left-sided SCPC was 10 and 16 months, respectively. The right-sided SCPC group included more aged patients (p = 0.045) and fewer patients who received postoperative chemotherapy (p = 0.034). When we focused on patients with macroscopically complete resection (n = 39), the MST and disease-free survival in the right-sided SCPC group was significantly shorter than in the left-sided SCPC group (p = 0.030 and p = 0.043, respectively). The MST of the right-sided and the left-sided SCPC patients among the completely resected patients was 24 and 73 months, respectively. Conclusion: Tumor sidedness may be a potent prognostic indicator for patients with SCPC. The survival time with right-sided SCPC is dramatically reduced compared to that with left-sided SCPC, especially among completely resected cases. We should change the treatment strategy according to the location of SCPC.
引用
收藏
页码:230 / 236
页数:7
相关论文
共 24 条
[1]   Primary Tumor Location and Survival in the General Population With Metastatic Colorectal Cancer [J].
Ahmed, Shahid ;
Pahwa, Punam ;
Le, Duc ;
Chalchal, Haji ;
Chandra-Kanthan, Selliah ;
Iqbal, Nayyer ;
Fields, Anthony .
CLINICAL COLORECTAL CANCER, 2018, 17 (02) :E201-E206
[2]   Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials [J].
Arnold, D. ;
Lueza, B. ;
Douillard, J. -Y. ;
Peeters, M. ;
Lenz, H. -J. ;
Venook, A. ;
Heinemann, V. ;
Van Cutsem, E. ;
Pignon, J. -P. ;
Tabernero, J. ;
Cervantes, A. ;
Ciardiello, F. .
ANNALS OF ONCOLOGY, 2017, 28 (08) :1713-1729
[3]   Primary tumor sidedness has an impact on prognosis and treatment outcome in metastatic colorectal cancer: results from two randomized first-line panitumumab studies [J].
Boeckx, N. ;
Koukakis, R. ;
de Beeck, K. Op ;
Rolfo, C. ;
Van Camp, G. ;
Siena, S. ;
Tabernero, J. ;
Douillard, J. -Y. ;
Andre, T. ;
Peeters, M. .
ANNALS OF ONCOLOGY, 2017, 28 (08) :1862-1868
[4]   The current practice of cytoreductive surgery and HIPEC for colorectal peritoneal metastases: Results of a worldwide web-based survey of the Peritoneal Surface Oncology Group International (PSOGI) [J].
Bushati, M. ;
Rovers, K. P. ;
Sommariva, A. ;
Sugarbaker, P. H. ;
Morris, D. L. ;
Yonemura, Y. ;
Quadros, C. A. ;
Somashekhar, S. P. ;
Ceelen, W. ;
Dube, P. ;
Li, Y. ;
Verwaal, V. J. ;
Glehen, O. ;
Piso, P. ;
Spiliotis, J. ;
Teo, M. C. C. ;
Gonzalez-Moreno, S. ;
Cashin, P. H. ;
Lehmann, K. ;
Deraco, M. ;
Moran, B. ;
de Hingh, I. H. J. T. .
EJSO, 2018, 44 (12) :1942-1948
[5]   The Impact of Primary Tumor Location on Long-Term Survival in Patients Undergoing Hepatic Resection for Metastatic Colon Cancer [J].
Creasy, John M. ;
Sadot, Eran ;
Koerkamp, Bas Groot ;
Chou, Joanne F. ;
Gonen, Mithat ;
Kemeny, Nancy E. ;
Saltz, Leonard B. ;
Balachandran, Vinod P. ;
Kingham, T. Peter ;
DeMatteo, Ronald P. ;
Allen, Peter J. ;
Jarnagin, William R. ;
D'Angelica, Michael I. .
ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (02) :431-438
[6]   Influence of the primary tumour location in patients undergoing surgery for colorectal liver metastases [J].
Dupre, Aurelien ;
Malik, Hassan Z. ;
Jones, Robert P. ;
Diaz-Nieto, Rafael ;
Fenwick, Stephen W. ;
Poston, Graeme J. .
EJSO, 2018, 44 (01) :80-86
[7]   Peritoneal Colorectal Carcinomatosis Treated With Surgery and Perioperative Intraperitoneal Chemotherapy: Retrospective Analysis of 523 Patients From a Multicentric French Study [J].
Elias, Dominique ;
Gilly, Francois ;
Boutitie, Florent ;
Quenet, Francois ;
Bereder, Jean-Marc ;
Mansvelt, Baudouin ;
Lorimier, Gerard ;
Dube, Pierre ;
Glehen, Olivier .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (01) :63-68
[8]   Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: A multi-institutional study [J].
Glehen, O ;
Kwiatkowski, F ;
Sugarbaker, PH ;
Elias, D ;
Levine, EA ;
De Simone, M ;
Barone, R ;
Yonemura, Y ;
Cavaliere, F ;
Quenet, F ;
Gutman, M ;
Tentes, AAK ;
Lorimier, G ;
Bernard, JL ;
Bereder, JM ;
Porcheron, J ;
Gomez-Portilla, A ;
Shen, P ;
Deraco, M ;
Rat, P ;
Gilly, FN .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (16) :3284-3292
[9]   The consensus molecular subtypes of colorectal cancer [J].
Guinney, Justin ;
Dienstmann, Rodrigo ;
Wang, Xin ;
de Reynies, Aurelien ;
Schlicker, Andreas ;
Soneson, Charlotte ;
Marisa, Laetitia ;
Roepman, Paul ;
Nyamundanda, Gift ;
Angelino, Paolo ;
Bot, Brian M. ;
Morris, Jeffrey S. ;
Simon, Iris M. ;
Gerster, Sarah ;
Fessler, Evelyn ;
Melo, Felipe De Sousa E. ;
Missiaglia, Edoardo ;
Ramay, Hena ;
Barras, David ;
Homicsko, Krisztian ;
Maru, Dipen ;
Manyam, Ganiraju C. ;
Broom, Bradley ;
Boige, Valerie ;
Perez-Villamil, Beatriz ;
Laderas, Ted ;
Salazar, Ramon ;
Gray, Joe W. ;
Hanahan, Douglas ;
Tabernero, Josep ;
Bernards, Rene ;
Friend, Stephen H. ;
Laurent-Puig, Pierre ;
Medema, Jan Paul ;
Sadanandam, Anguraj ;
Wessels, Lodewyk ;
Delorenzi, Mauro ;
Kopetz, Scott ;
Vermeulen, Louis ;
Tejpar, Sabine .
NATURE MEDICINE, 2015, 21 (11) :1350-1356
[10]   Does Primary Tumor Side Matter in Patients with Metastatic Colon Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy? [J].
Kelly, Kaitlyn J. ;
Alsayadnasser, Masumah ;
Vaida, Florin ;
Veerapong, Jula ;
Baumgartner, Joel M. ;
Patel, Sameer ;
Ahmad, Syed ;
Barone, Robert ;
Lowy, Andrew M. .
ANNALS OF SURGICAL ONCOLOGY, 2019, 26 (05) :1421-1427